TY  - JOUR
VL  - 9
AV  - public
SP  - 2588
Y1  - 2020///
EP  - 2596
TI  - COVID-19 In Children Across Three Asian Cosmopolitan Regions
IS  - 1
N1  - © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UR  - https://doi.org/10.1080/22221751.2020.1846462
N2  - As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p?<?0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p?<?0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p?<?0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p?<?0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p=0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin (p?=?0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age.
ID  - discovery10114177
A1  - Chua, GT
A1  - Xiong, X
A1  - Choi, EH
A1  - Han, MS
A1  - Chang, SH
A1  - Jin, BL
A1  - Lee, EJ
A1  - Kim, BN
A1  - Kim, MK
A1  - Doo, K
A1  - Seo, JH
A1  - Kim, YJ
A1  - Kim, YJ
A1  - Park, JY
A1  - Suh, SB
A1  - Lee, H
A1  - Cho, EY
A1  - Kim, DH
A1  - Kim, JM
A1  - Kim, HY
A1  - Park, SE
A1  - Lee, JK
A1  - Jo, DS
A1  - Cho, SM
A1  - Choi, JH
A1  - Jo, KJ
A1  - Choe, YJ
A1  - Kim, KH
A1  - Chi, S
A1  - Tang, S-T
A1  - Qin, H
A1  - Zhou, LS
A1  - Chen, P
A1  - Wong, JSC
A1  - Chan, KCC
A1  - Yau, FYS
A1  - Lam, SY
A1  - Chow, CCK
A1  - Wong, TW
A1  - Chan, V
A1  - Poon, GWK
A1  - Chow, CB
A1  - Wong, WH
A1  - Lau, YL
A1  - Chan, GCF
A1  - Chui, CS
A1  - Li, X
A1  - Ho, MHK
A1  - Wong, IC
A1  - Tam, PKH
A1  - To, KK
A1  - Kim, JH
A1  - Ip, P
A1  - Kwan, MYW
JF  - Emerging Microbes & Infections
ER  -