eprintid: 10113775 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/11/37/75 datestamp: 2020-11-02 11:29:34 lastmod: 2021-10-15 23:09:43 status_changed: 2020-11-02 11:29:34 type: article metadata_visibility: show creators_name: Doolan, PJ creators_name: Collins-Fekete, C-A creators_name: Dias, MF creators_name: Ruggieri, TA creators_name: D'Souza, D creators_name: Seco, J title: Inter-comparison of relative stopping power estimation models for proton therapy ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: Theoretical stopping power values were inter-compared for the Bichsel, Janni, ICRU and Schneider relative stopping power (RSP) estimation models, for a variety of tissues and tissue substitute materials taken from the literature. The RSPs of eleven plastic tissue substitutes were measured using Bragg peak shift measurements in water in order to establish a gold standard of RSP values specific to our centre's proton beam characteristics. The theoretical tissue substitute RSP values were computed based on literature compositions to assess the four different computation approaches. The Bichsel/Janni/ICRU approaches led to mean errors in the RSP of −0.1/+0.7/−0.8%, respectively. Errors when using the Schneider approach, with I-values from the Bichsel, Janni and ICRU sources, followed the same pattern but were generally larger. Following this, the mean elemental ionisation energies were optimized until the differences between theoretical RSP values matched measurements. Failing to use optimized I-values when applying the Schneider technique to 72 human tissues could introduce errors in the RSP of up to −1.7/+1.1/−0.4% when using Bichsel/Janni/ICRU I-values, respectively. As such, it may be necessary to introduce an additional step in the current stoichiometric calibration procedure in which tissue insert RSPs are measured in a proton beam. Elemental I-values can then optimized to match these measurements, reducing the uncertainty when calculating human tissue RSPs. date: 2016-11-21 date_type: published publisher: IOP PUBLISHING LTD official_url: https://doi.org/10.1088/0031-9155/61/22/8085 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1188959 doi: 10.1088/0031-9155/61/22/8085 lyricists_name: Collins Fekete, Charles-Antoine lyricists_name: Doolan, Paul lyricists_id: CCOLL52 lyricists_id: PJDOO30 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: Physics in Medicine & Biology volume: 61 number: 22 article_number: 8085 pages: 20 citation: Doolan, PJ; Collins-Fekete, C-A; Dias, MF; Ruggieri, TA; D'Souza, D; Seco, J; (2016) Inter-comparison of relative stopping power estimation models for proton therapy. Physics in Medicine & Biology , 61 (22) , Article 8085. 10.1088/0031-9155/61/22/8085 <https://doi.org/10.1088/0031-9155%2F61%2F22%2F8085>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10113775/1/Collins%20FeketeInter-comparison%20of%20relative%20stopping%20power%20estimation%20models%20for%20proton%20therapy_AAM.pdf