eprintid: 10113178 rev_number: 16 eprint_status: archive userid: 608 dir: disk0/10/11/31/78 datestamp: 2020-10-27 11:05:17 lastmod: 2021-09-19 22:17:59 status_changed: 2020-10-27 11:05:17 type: article metadata_visibility: show creators_name: Carvalho, PD creators_name: Ruyssen-Witrand, A creators_name: Fonseca, J creators_name: Marreiros, A creators_name: Machado, PM title: Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort ispublished: pub subjects: UCH divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F85 keywords: Ankylosing, MRI, Patient Reported Outcome Measures, Spondylitis note: © Author(s) (or their employer[s]) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (http://creativecommons.org/licenses/by-nc/4.0/). abstract: OBJECTIVE: To investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA). METHODS: Five-year longitudinal data from the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders. RESULTS: Data from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation. CONCLUSION: In early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages. date: 2020-09 date_type: published official_url: http://dx.doi.org/10.1136/rmdopen-2020-001356 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1823883 doi: 10.1136/rmdopen-2020-001356 pii: rmdopen-2020-001356 lyricists_name: Machado, Pedro lyricists_id: PMMAC99 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: RMD Open volume: 6 number: 3 article_number: e001356 event_location: England citation: Carvalho, PD; Ruyssen-Witrand, A; Fonseca, J; Marreiros, A; Machado, PM; (2020) Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort. RMD Open , 6 (3) , Article e001356. 10.1136/rmdopen-2020-001356 <https://doi.org/10.1136/rmdopen-2020-001356>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10113178/1/e001356.full.pdf