eprintid: 10113178
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/11/31/78
datestamp: 2020-10-27 11:05:17
lastmod: 2021-09-19 22:17:59
status_changed: 2020-10-27 11:05:17
type: article
metadata_visibility: show
creators_name: Carvalho, PD
creators_name: Ruyssen-Witrand, A
creators_name: Fonseca, J
creators_name: Marreiros, A
creators_name: Machado, PM
title: Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F85
keywords: Ankylosing, MRI, Patient Reported Outcome Measures, Spondylitis
note: © Author(s) (or their employer[s]) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (http://creativecommons.org/licenses/by-nc/4.0/).
abstract: OBJECTIVE: To investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA). METHODS: Five-year longitudinal data from the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders. RESULTS: Data from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation. CONCLUSION: In early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.
date: 2020-09
date_type: published
official_url: http://dx.doi.org/10.1136/rmdopen-2020-001356
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1823883
doi: 10.1136/rmdopen-2020-001356
pii: rmdopen-2020-001356
lyricists_name: Machado, Pedro
lyricists_id: PMMAC99
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: RMD Open
volume: 6
number: 3
article_number: e001356
event_location: England
citation:        Carvalho, PD;    Ruyssen-Witrand, A;    Fonseca, J;    Marreiros, A;    Machado, PM;      (2020)    Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort.                   RMD Open , 6  (3)    , Article e001356.  10.1136/rmdopen-2020-001356 <https://doi.org/10.1136/rmdopen-2020-001356>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10113178/1/e001356.full.pdf