eprintid: 10113092 rev_number: 34 eprint_status: archive userid: 608 dir: disk0/10/11/30/92 datestamp: 2020-10-26 14:21:19 lastmod: 2021-11-18 15:44:37 status_changed: 2020-10-26 14:21:19 type: article metadata_visibility: show creators_name: Abrahams, HJG creators_name: Knoop, H creators_name: Schreurs, M creators_name: Aaronson, NK creators_name: Jacobsen, PB creators_name: Newton, RU creators_name: Courneya, KS creators_name: Aitken, JF creators_name: Arving, C creators_name: Brandberg, Y creators_name: Chambers, SK creators_name: Gielissen, MFM creators_name: Glimelius, B creators_name: Goedendorp, MM creators_name: Graves, KD creators_name: Heiney, SP creators_name: Horne, R creators_name: Hunter, MS creators_name: Johansson, B creators_name: Northouse, LL creators_name: Oldenburg, HSA creators_name: Prins, JB creators_name: Savard, J creators_name: van Beurden, M creators_name: van den Berg, SW creators_name: Verdonck-de Leeuw, IM creators_name: Buffart, LM title: Moderators of the effect of psychosocial interventions on fatigue in women with breast cancer and men with prostate cancer: Individual patient data meta‐analyses ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G11 keywords: breast cancer, cancer, fatigue, individual patient data meta-analysis, moderators, oncology, prostate cancer, psycho-oncology, psychosocial interventions note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Objective: Psychosocial interventions can reduce cancer‐related fatigue effectively. However, it is still unclear if intervention effects differ across subgroups of patients. These meta‐analyses aimed at evaluating moderator effects of (a) sociodemographic characteristics, (b) clinical characteristics, (c) baseline levels of fatigue and other symptoms, and (d) intervention‐related characteristics on the effect of psychosocial interventions on cancer‐related fatigue in patients with non‐metastatic breast and prostate cancer. / Methods: Data were retrieved from the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) consortium. Potential moderators were studied with meta‐analyses of pooled individual patient data from 14 randomized controlled trials through linear mixed‐effects models with interaction tests. The analyses were conducted separately in patients with breast (n = 1091) and prostate cancer (n = 1008). / Results: Statistically significant, small overall effects of psychosocial interventions on fatigue were found (breast cancer: β = −0.19 [95% confidence interval (95%CI) = −0.30; −0.08]; prostate cancer: β = −0.11 [95%CI = −0.21; −0.00]). In both patient groups, intervention effects did not differ significantly by sociodemographic or clinical characteristics, nor by baseline levels of fatigue or pain. For intervention‐related moderators (only tested among women with breast cancer), statistically significant larger effects were found for cognitive behavioral therapy as intervention strategy (β = −0.27 [95%CI = −0.40; −0.15]), fatigue‐specific interventions (β = −0.48 [95%CI = −0.79; −0.18]), and interventions that only targeted patients with clinically relevant fatigue (β = −0.85 [95%CI = −1.40; −0.30]). / Conclusions: Our findings did not provide evidence that any selected demographic or clinical characteristic, or baseline levels of fatigue or pain, moderated effects of psychosocial interventions on fatigue. A specific focus on decreasing fatigue seems beneficial for patients with breast cancer with clinically relevant fatigue. date: 2020-11 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/pon.5522 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1812877 doi: 10.1002/pon.5522 lyricists_name: Horne, Robert lyricists_id: RHORN95 actors_name: Jayawardana, Anusha actors_id: AJAYA51 actors_role: owner full_text_status: public publication: Psycho-Oncology volume: 29 number: 11 pagerange: 1772-1785 pages: 14 issn: 1099-1611 citation: Abrahams, HJG; Knoop, H; Schreurs, M; Aaronson, NK; Jacobsen, PB; Newton, RU; Courneya, KS; ... Buffart, LM; + view all <#> Abrahams, HJG; Knoop, H; Schreurs, M; Aaronson, NK; Jacobsen, PB; Newton, RU; Courneya, KS; Aitken, JF; Arving, C; Brandberg, Y; Chambers, SK; Gielissen, MFM; Glimelius, B; Goedendorp, MM; Graves, KD; Heiney, SP; Horne, R; Hunter, MS; Johansson, B; Northouse, LL; Oldenburg, HSA; Prins, JB; Savard, J; van Beurden, M; van den Berg, SW; Verdonck-de Leeuw, IM; Buffart, LM; - view fewer <#> (2020) Moderators of the effect of psychosocial interventions on fatigue in women with breast cancer and men with prostate cancer: Individual patient data meta‐analyses. Psycho-Oncology , 29 (11) pp. 1772-1785. 10.1002/pon.5522 <https://doi.org/10.1002/pon.5522>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10113092/1/Horne_POLARIS_final%20version%20manuscript_moderators%20psychosocial%20interventions%20for%20fatigue.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10113092/6/Horne_POLARIS_final%20version%20figures%2Btables_moderators%20psychosocial%20interventions%20for%20fatigue.pdf