<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10113045> <http://purl.org/dc/terms/title> "Pre-diagnostic biomarkers of type 2 diabetes identified in the UAE's obese national population using targeted metabolomics"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10113045> <http://purl.org/ontology/bibo/abstract> "Currently, type 2 diabetes mellitus (T2DM) and obesity are major global public health issues, and\r\ntheir prevalence in the United Arab Emirates (UAE) are among the highest in the world. In 2019,\r\nThe UAE diabetes national prevalence was 15.4%. In recent years there has been a considerable\r\ninvestigation of predictive biomarkers associated with these conditions. This study analysed\r\nfasting (8 h) blood samples from an obese, normoglycemic cohort and an obese, T2DM cohort of\r\nUAE nationals, employing clinical chemistry analysis, 1D 1\r\nH NMR and mass spectroscopy (FIA-MS/\r\nMS and LC-MS/MS) techniques. The novel fndings reported for the frst time in a UAE population\r\nrevealed signifcant diferences in a number of metabolites in the T2DM cohort. Metabolic fngerprints\r\nidentifed by NMR included BCAAs, trimethylamine N-oxide, β-hydroxybutyrate, trimethyl uric acid,\r\nand alanine. A targeted MS approach showed signifcant diferences in lysophosphatidylcholines,\r\nphosphatidylcholines, acylcarnitine, amino acids and sphingomyelins; Lyso.PC.a.C18.0, PC.ae.C34.2,\r\nC3.DC..C4.OH, glutamine and SM.C16.1, being the most signifcant metabolites. Pearson’s correlation\r\nstudies showed associations between these metabolites and the clinical chemistry parameters across\r\nboth cohorts. This report identifed diferences in metabolites in response to T2DM in agreement with\r\nmany published population studies. This contributes to the global search for a bank of metabolite\r\nbiomarkers that can predict the advent of T2DM and give insight to its pathogenic mechanisms."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10113045> <http://purl.org/dc/terms/date> "2020-10-19" .
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<https://discovery.ucl.ac.uk/id/eprint/10113045/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10113045 \n\nPre-diagnostic biomarkers of type 2 diabetes identified in the UAE's obese national population using targeted metabolomics\n\n" .
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<https://discovery.ucl.ac.uk/id/eprint/10113045/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10113045> .