eprintid: 10112715 rev_number: 18 eprint_status: archive userid: 608 dir: disk0/10/11/27/15 datestamp: 2020-10-21 10:28:46 lastmod: 2021-09-26 22:21:37 status_changed: 2020-10-21 10:28:46 type: article metadata_visibility: show creators_name: Li, N creators_name: Mrsic-Flogel, TD title: Cortico-cerebellar interactions during goal-directed behavior ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D75 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: Preparatory activity is observed across multiple interconnected brain regions before goal-directed movement. Preparatory activity reflects discrete activity states representing specific future actions. It is unclear how this activity is mediated by multi-regional interactions. Recent evidence suggests that the cerebellum, classically associated with fine motor control, contributes to preparatory activity in the neocortex. We review recent advances and offer perspective on the function of cortico-cerebellar interactions during goal-directed behavior. We propose that the cerebellum learns to facilitate transitions between neocortical activity states. Transitions between activity states enable flexible and appropriately timed behavioral responses. date: 2020-12 date_type: published official_url: https://doi.org/10.1016/j.conb.2020.08.010 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1816580 doi: 10.1016/j.conb.2020.08.010 pii: S0959-4388(20)30123-9 lyricists_name: Mrsic-Flogel, Dobrisa lyricists_id: TMRSI56 actors_name: Mrsic-Flogel, Dobrisa actors_name: Bennett, Emma actors_id: TMRSI56 actors_id: EBENN72 actors_role: owner actors_role: impersonator full_text_status: public publication: Current Opinion in Neurobiology volume: 65 pagerange: 27-37 event_location: England citation: Li, N; Mrsic-Flogel, TD; (2020) Cortico-cerebellar interactions during goal-directed behavior. Current Opinion in Neurobiology , 65 pp. 27-37. 10.1016/j.conb.2020.08.010 <https://doi.org/10.1016/j.conb.2020.08.010>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10112715/3/Mrsic-Flogel_Cortico-cerebellar%20interactions%20during%20goal-directed%20behavior_AAM.pdf