eprintid: 10112299
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/11/22/99
datestamp: 2020-10-16 09:44:52
lastmod: 2021-10-12 21:55:57
status_changed: 2020-10-16 09:44:52
type: article
metadata_visibility: show
creators_name: Papasavvas, C
creators_name: Schroeder, G
creators_name: Diehl, B
creators_name: Baier, G
creators_name: Taylor, PN
creators_name: Wang, Y
title: Band power modulation through intracranial EEG stimulation and its cross-session consistency
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F81
divisions: C08
divisions: D09
divisions: F96
keywords: brain stimulation, direct electrical stimulation, drug-resistant epilepsy, electrocorticogram, frequency bands, neuromodulation, response variability
note: This work is licensed under a Creative Commons Attribution 3.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
abstract: Objective: Direct electrical stimulation of the brain through intracranial electrodes is currently used to probe the epileptic brain as part of pre-surgical evaluation, and it is also being considered for therapeutic treatments through neuromodulation. In order to effectively modulate neural activity, a given neuromodulation design must elicit similar responses throughout the course of treatment. However, it is unknown whether intracranial electrical stimulation responses are consistent across sessions. The objective of this study was to investigate the within-subject, cross-session consistency of the electrophysiological effect of electrical stimulation delivered through intracranial EEG. Approach: We analysed data from 79 epilepsy patients implanted with intracranial EEG who underwent brain stimulation as part of a memory experiment. We quantified the effect of stimulation in terms of band power modulation and compared this effect from session to session. As a reference, we made the same measurements during baseline periods. Main results: In most sessions, the effect of stimulation on band power could not be distinguished from baseline fluctuations of band power. Stimulation effect was consistent in a third of the session pairs, while the rest had a consistency measure not exceeding the baseline standards. Cross-session consistency was highly correlated with the degree of band power increase, and it also tended to be higher when the baseline conditions were more similar between sessions. Significance: These findings can inform our practices for designing neuromodulation with greater efficacy when using direct electrical brain stimulation as a therapeutic treatment.
date: 2020-10-06
official_url: https://doi.org/10.1088/1741-2552/abbecf
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1788116
doi: 10.1088/1741-2552/abbecf
lyricists_name: Baier, Gerold
lyricists_name: Diehl, Beate
lyricists_id: GBAIE50
lyricists_id: BDIEH56
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Neural Engineering
event_location: England
citation:        Papasavvas, C;    Schroeder, G;    Diehl, B;    Baier, G;    Taylor, PN;    Wang, Y;      (2020)    Band power modulation through intracranial EEG stimulation and its cross-session consistency.                   Journal of Neural Engineering        10.1088/1741-2552/abbecf <https://doi.org/10.1088/1741-2552%2Fabbecf>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10112299/1/Papasavvas%2Bet%2Bal_2020_J._Neural_Eng._10.1088_1741-2552_abbecf.pdf