TY  - JOUR
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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IS  - 3
EP  - 19
AV  - public
VL  - 5
Y1  - 2020/05/01/
TI  - HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Microbiology
KW  -  HIV
KW  -  antibodies
KW  -  coinfection
KW  -  humoral immunity
KW  -  tuberculosis
KW  -  HEMOLYSIN-FORMING CELLS
KW  -  FC-GAMMA RECEPTORS
KW  -  MYCOBACTERIUM-TUBERCULOSIS
KW  -  ANTIBODY-RESPONSES
KW  -  B-CELLS
KW  -  ANTIRETROVIRAL THERAPY
KW  -  HIGH-THROUGHPUT
KW  -  T-CELLS
KW  -  INFECTION
KW  -  ANTIGEN
A1  - Woudenbergh, EV
A1  - Irvine, EB
A1  - Davies, L
A1  - Kock, MD
A1  - Hanekom, WA
A1  - Day, CL
A1  - Fortune, S
A1  - Alter, G
JF  - mSphere
UR  - https://doi.org/10.1128/mSphere.00104-20
PB  - AMER SOC MICROBIOLOGY
ID  - discovery10112190
N2  - Tuberculosis (TB) represents the largest cause of death in human immunodeficiency virus (HIV)-infected individuals in part due to HIV-related CD4+ T cell loss, rendering patients immunocompromised and susceptible to a loss of Mycobacterium tuberculosis control. However, in light of increasing data pointing to a role for humoral immunity in controlling M. tuberculosis infection, here, we aimed to define whether HIV infection also alters the humoral immune response in subjects with active and latent TB. We show that in the setting of active TB, HIV-positive individuals have significantly lower IgG responses to LAM and Ag85 than HIV-negative individuals. Furthermore, significant isotype/subclass-specific differences were frequently observed, with active TB, HIV-positive individuals demonstrating compromised antigen-specific IgM titers. HIV-infected individuals with active TB also exhibited a significant loss of influenza hemagglutinin- and tetanus toxoid-specific antibody titers at the isotype/subclass level, a symptom of broad humoral immune dysfunction likely precipitated by HIV infection. Finally, we illustrated that despite the influence of HIV infection, differences in M. tuberculosis-specific antibody profiles persist between latent and active TB disease. Taken together, these findings reveal significant HIV-associated disruptions of the humoral immune response in HIV/TB-coinfected individuals.
ER  -