eprintid: 10112054 rev_number: 19 eprint_status: archive userid: 608 dir: disk0/10/11/20/54 datestamp: 2020-10-14 10:18:01 lastmod: 2021-12-17 11:34:20 status_changed: 2020-10-14 10:18:01 type: article metadata_visibility: show creators_name: Berke Göztepe, M creators_name: Görkem Özyurt, M creators_name: Sitki Türker, K creators_name: Uysal, H title: Comparison of the temporal properties of medium latency responses induced by cortical and peripheral stimulation ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F85 keywords: transcranial magnetic stimulation, medium latency reflex, motor evoked potential, spinal circuits, reflexes note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. abstract: Sudden foot dorsiflexion lengthens soleus muscle and activates stretch-based spinal reflexes. Dorsiflexion can be triggered by activating tibialis anterior (TA) muscle through peroneal nerve stimulation or transcranial magnetic stimulation (TMS) which evokes a response in the soleus muscle referred to as Medium Latency Reflex (MLR) or motor-evoked potential-80 (Soleus MEP80), respectively. This study aimed to examine the relationship between these responses in humans. Therefore, latency characteristics and correlation of responses between soleus MEP80 and MLR were investigated. We have also calculated the latencies from the onset of tibialis activity, i.e., subtracting of TA-MEP from MEP80 and TA direct motor response from MLR. We referred to these calculations as Stretch Loop Latency Central (SLLc) for MEP80 and Stretch Loop Latency Peripheral (SLLp) for MLR. The latency of SLLc was found to be 61.4 ± 5.6 ms which was significantly shorter (P = 0.0259) than SLLp (64.0 ± 4.2 ms) and these latencies were correlated (P = 0.0045, r = 0.689). The latency of both responses was also found to be inversely related to the response amplitude (P = 0.0121, r = 0.451) probably due to the activation of large motor units. When amplitude differences were corrected, i.e. investigating the responses with similar amplitudes, SLLp, and SLLc latencies found to be similar (P = 0.1317). Due to the identical features of the soleus MEP80 and MLR, we propose that they may both have spinal origins. date: 2020-12 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.jelekin.2020.102477 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1821030 doi: 10.1016/j.jelekin.2020.102477 lyricists_name: Ozyurt, Mustafa lyricists_id: MGOZY54 actors_name: Ozyurt, Mustafa actors_id: MGOZY54 actors_role: owner full_text_status: public publication: Journal of Electromyography and Kinesiology volume: 55 article_number: 102477 citation: Berke Göztepe, M; Görkem Özyurt, M; Sitki Türker, K; Uysal, H; (2020) Comparison of the temporal properties of medium latency responses induced by cortical and peripheral stimulation. Journal of Electromyography and Kinesiology , 55 , Article 102477. 10.1016/j.jelekin.2020.102477 <https://doi.org/10.1016/j.jelekin.2020.102477>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10112054/1/10.1016%40j.jelekin.2020.102477.pdf