eprintid: 10111454 rev_number: 19 eprint_status: archive userid: 608 dir: disk0/10/11/14/54 datestamp: 2020-10-06 14:29:48 lastmod: 2021-12-06 23:48:19 status_changed: 2020-10-06 14:29:48 type: article metadata_visibility: show creators_name: Facchinetti, F creators_name: Cavalli, P creators_name: Copp, AJ creators_name: D'Anna, R creators_name: Kandaraki, E creators_name: Greene, NDE creators_name: Unfer, V title: An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs) ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G22 keywords: D-chiro-inositol (DCI), gestational diabetes mellitus (GDM), insulin resistance, myo-inositol (MI), neural tube defects (NTDs), prevention note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions. date: 2020 date_type: published official_url: http://dx.doi.org/10.1080/17425255.2020.1828344 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1816525 doi: 10.1080/17425255.2020.1828344 lyricists_name: Copp, Andrew lyricists_name: Greene, Nicholas lyricists_id: ACOPP78 lyricists_id: NDEGR34 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Expert Opinion on Drug Metabolism & Toxicology volume: 16 number: 12 pagerange: 1189-1198 event_location: England citation: Facchinetti, F; Cavalli, P; Copp, AJ; D'Anna, R; Kandaraki, E; Greene, NDE; Unfer, V; (2020) An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opinion on Drug Metabolism & Toxicology , 16 (12) pp. 1189-1198. 10.1080/17425255.2020.1828344 <https://doi.org/10.1080/17425255.2020.1828344>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10111454/1/An%20update%20on%20the%20use%20of%20inositols%20in%20preventing%20gestational%20diabetes%20mellitus%20GDM%20and%20neural%20tube%20defects%20NTDs.pdf