eprintid: 10111454
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/11/14/54
datestamp: 2020-10-06 14:29:48
lastmod: 2021-12-06 23:48:19
status_changed: 2020-10-06 14:29:48
type: article
metadata_visibility: show
creators_name: Facchinetti, F
creators_name: Cavalli, P
creators_name: Copp, AJ
creators_name: D'Anna, R
creators_name: Kandaraki, E
creators_name: Greene, NDE
creators_name: Unfer, V
title: An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: D-chiro-inositol (DCI), gestational diabetes mellitus (GDM), insulin resistance, myo-inositol (MI), neural tube defects (NTDs), prevention
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.
date: 2020
date_type: published
official_url: http://dx.doi.org/10.1080/17425255.2020.1828344
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1816525
doi: 10.1080/17425255.2020.1828344
lyricists_name: Copp, Andrew
lyricists_name: Greene, Nicholas
lyricists_id: ACOPP78
lyricists_id: NDEGR34
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Expert Opinion on Drug Metabolism & Toxicology
volume: 16
number: 12
pagerange: 1189-1198
event_location: England
citation:        Facchinetti, F;    Cavalli, P;    Copp, AJ;    D'Anna, R;    Kandaraki, E;    Greene, NDE;    Unfer, V;      (2020)    An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs).                   Expert Opinion on Drug Metabolism & Toxicology , 16  (12)   pp. 1189-1198.    10.1080/17425255.2020.1828344 <https://doi.org/10.1080/17425255.2020.1828344>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10111454/1/An%20update%20on%20the%20use%20of%20inositols%20in%20preventing%20gestational%20diabetes%20mellitus%20GDM%20and%20neural%20tube%20defects%20NTDs.pdf