TY  - JOUR
A1  - Facchinetti, F
A1  - Cavalli, P
A1  - Copp, AJ
A1  - D'Anna, R
A1  - Kandaraki, E
A1  - Greene, NDE
A1  - Unfer, V
N2  - INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.
KW  - D-chiro-inositol (DCI)
KW  -  gestational diabetes mellitus (GDM)
KW  -  insulin resistance
KW  -  myo-inositol (MI)
KW  -  neural tube defects (NTDs)
KW  -  prevention
SP  - 1189
EP  - 1198
IS  - 12
AV  - public
ID  - discovery10111454
Y1  - 2020///
UR  - http://dx.doi.org/10.1080/17425255.2020.1828344
TI  - An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
JF  - Expert Opinion on Drug Metabolism & Toxicology
VL  - 16
ER  -