TY  - JOUR
ID  - discovery10111422
UR  - https://doi.org/10.1016/j.brainres.2020.147135
Y1  - 2020/12/15/
TI  - Endocannabinoid system alterations in Alzheimer's disease: a systematic review of human studies
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
JF  - Brain Research
VL  - 1749
A1  - Berry, AJ
A1  - Zubko, O
A1  - Reeves, SJ
A1  - Howard, RJ
KW  - 2-arachidonoylglycerol
KW  -  Alzheimer
KW  -  TRPV1
KW  -  anandamide
KW  -  cannabinoid receptor
KW  -  endocannabinoid
KW  -  fatty acid amide hydrolase
KW  -  monoacylglycerol
KW  -  neurodegeneration
N2  - Studies investigating alterations of the endocannabinoid system (ECS) in Alzheimer's disease (AD) in humans have reported inconsistent findings so far. We performed a systematic review of studies examining alterations of the ECS specifically within humans with AD or mild cognitive impairment (MCI), including neuroimaging studies, studies of serum and cerebrospinal fluid biomarkers, and post-mortem studies. We attempted to identify reported changes in the expression and activity of: cannabinoid receptors 1 and 2; anandamide (AEA); 2-arachidonoylglycerol (2-AG); monoacylglycerol lipase (MAGL); fatty acid amide hydrolase (FAAH); and transient receptor potential cation channel V1 (TRPV1). Twenty-two studies were identified for inclusion. Mixed findings were reported for most aspects of the ECS in AD, making it difficult to identify a particular profile of ECS alterations characterising AD. The included studies tended to be small, methodologically heterogeneous, and frequently did not control for important potential confounders, such as pathological progression of AD. Eight studies correlated ECS alterations with neuropsychometric performance measures, though studies infrequently examined behavioural and neuropsychiatric correlates. PROSPERO database identifier: CRD42018096249.
AV  - public
ER  -