<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10111139> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/title> "Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/abstract> "The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 continues. We have witnessed anecdotal use of herbal medicines, including Artemisia spp. extracts, in low-income countries, and exaggerated claims of their efficacies that are not evidence based, with subsequent political controversy. These events highlight the urgent need for further research on herbal compounds to evaluate efficacy through RCTs, and, when efficacious compounds are identified, to establish the active ingredients, develop formulations and dosing, and define pharmacokinetics, toxicology, and safety to enable drug development. Derivatives from the herb Artemisia annua have been used as traditional medicine over centuries for the treatment of fevers, malaria, and respiratory tract infections. We review the bioactive compounds, pharmacological and immunological effects, and traditional uses for Artemisia spp. derivatives, and discuss the challenges and controversies surrounding current efforts and the scientific road map to advance them to prevent or treat COVID-19."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/date> "2020-09-02" . <https://discovery.ucl.ac.uk/id/document/1184391> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/volume> "103" . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/issue> "3" . <https://discovery.ucl.ac.uk/id/publication/ext-6d9b1bcf8cb5ab86242361064de29c6b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-6d9b1bcf8cb5ab86242361064de29c6b> <http://xmlns.com/foaf/0.1/name> "The American Journal of Tropical Medicine and Hygiene"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-6d9b1bcf8cb5ab86242361064de29c6b> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1ac9359878707ed9dd2d75ae3a849037> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-1ac9359878707ed9dd2d75ae3a849037> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-af0501fcae9a832c6b1b597ba772a921> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-af0501fcae9a832c6b1b597ba772a921> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-aaa100ad48ea088d12a89a3d4e985acd> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-aaa100ad48ea088d12a89a3d4e985acd> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7d21226aa5ce5ff751de50055c57fd11> . <https://discovery.ucl.ac.uk/id/eprint/10111139> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111139#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-7d21226aa5ce5ff751de50055c57fd11> . <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> <http://xmlns.com/foaf/0.1/familyName> "Zumla"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-85d0309878d204c41d9eb05bb04135c8> <http://xmlns.com/foaf/0.1/name> "A Zumla"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> <http://xmlns.com/foaf/0.1/familyName> "Decloedt"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5b64038cc2f50787445121b6de8c752c> <http://xmlns.com/foaf/0.1/name> "E Decloedt"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> <http://xmlns.com/foaf/0.1/familyName> "Tiberi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-18641aab5ba76128000497dfadfc8ac8> <http://xmlns.com/foaf/0.1/name> "S Tiberi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> <http://xmlns.com/foaf/0.1/givenName> "J-J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> <http://xmlns.com/foaf/0.1/familyName> "Muyembe-TamFum"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4232a58472332c05423fb620b7949097> <http://xmlns.com/foaf/0.1/name> "J-J Muyembe-TamFum"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> <http://xmlns.com/foaf/0.1/givenName> "PM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> <http://xmlns.com/foaf/0.1/familyName> "Kapepula"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6ac0d8e8a259962a1ae98f5256cb4ba9> <http://xmlns.com/foaf/0.1/name> "PM Kapepula"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> <http://xmlns.com/foaf/0.1/givenName> "JK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> <http://xmlns.com/foaf/0.1/familyName> "Kabengele"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-44a3bcdb9bcb40f400be1af84f6ad26b> <http://xmlns.com/foaf/0.1/name> "JK Kabengele"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> <http://xmlns.com/foaf/0.1/familyName> "Tshilolo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3682c260571fd67fbcbc9fdc432843f7> <http://xmlns.com/foaf/0.1/name> "L Tshilolo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> <http://xmlns.com/foaf/0.1/familyName> "Van Bambeke"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-270baa717d35934b017386ff14476685> <http://xmlns.com/foaf/0.1/name> "F Van Bambeke"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> <http://xmlns.com/foaf/0.1/familyName> "Kingombe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7a86b61bb1a46967cc1cc6719c09646> <http://xmlns.com/foaf/0.1/name> "M Kingombe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7d21226aa5ce5ff751de50055c57fd11> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> 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