eprintid: 10111112
rev_number: 34
eprint_status: archive
userid: 608
dir: disk0/10/11/11/12
datestamp: 2020-10-01 14:51:36
lastmod: 2021-12-03 17:43:42
status_changed: 2020-10-01 14:51:36
type: article
metadata_visibility: show
creators_name: Giganti, F
creators_name: Stavrinides, V
creators_name: Stabile, A
creators_name: Osinibi, E
creators_name: Orczyk, C
creators_name: Radtke, JP
creators_name: Freeman, A
creators_name: Haider, A
creators_name: Punwani, S
creators_name: Allen, C
creators_name: Emberton, M
creators_name: Kirkham, A
creators_name: Moore, CM
title: Prostate cancer measurements on serial MRI during active surveillance: it’s time to be PRECISE
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: FI6
divisions: D16
divisions: G88
note: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVE: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. METHODS: We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on T2 weighted imaging (T2WI) according to all definitions. A PRECISE score was assessed for each patient. RESULTS: The ellipsoid formula exhibited the highest correlation with planimetry at baseline (ρ = 0.97) and follow-up (ρ = 0.98) imaging, compared to the biaxial measurement and single maximum diameter. There was a significant difference (p < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) for planimetry (39.64%) and for the ellipsoid formula (46.78%). CONCLUSION: The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed. ADVANCES IN KNOWLEDGE: The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on T2WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.
date: 2020-12
date_type: published
official_url: http://dx.doi.org/10.1259/bjr.20200819
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1816062
doi: 10.1259/bjr.20200819
lyricists_name: Emberton, Mark
lyricists_name: Giganti, Francesco
lyricists_name: Moore, Caroline
lyricists_name: Orczyk, Clement
lyricists_name: Punwani, Shonit
lyricists_name: Stavrinides, Vasilis
lyricists_id: MEMBE52
lyricists_id: FGIGA51
lyricists_id: CMMOO61
lyricists_id: CORCZ53
lyricists_id: SPUNW14
lyricists_id: VSTAV68
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: British Journal of Radiology
volume: 93
number: 1116
article_number: 20200819
event_location: England
citation:        Giganti, F;    Stavrinides, V;    Stabile, A;    Osinibi, E;    Orczyk, C;    Radtke, JP;    Freeman, A;                         ... Moore, CM; + view all <#>        Giganti, F;  Stavrinides, V;  Stabile, A;  Osinibi, E;  Orczyk, C;  Radtke, JP;  Freeman, A;  Haider, A;  Punwani, S;  Allen, C;  Emberton, M;  Kirkham, A;  Moore, CM;   - view fewer <#>    (2020)    Prostate cancer measurements on serial MRI during active surveillance: it’s time to be PRECISE.                   British Journal of Radiology , 93  (1116)    , Article 20200819.  10.1259/bjr.20200819 <https://doi.org/10.1259/bjr.20200819>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10111112/1/bjr.20200819.pdf