eprintid: 10111044
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/11/10/44
datestamp: 2020-09-30 09:19:46
lastmod: 2021-12-20 00:51:31
status_changed: 2020-09-30 09:19:46
type: article
metadata_visibility: show
creators_name: Tanabe, S
creators_name: Bo, A
creators_name: White, M
creators_name: Parker, M
creators_name: Farahbakhsh, Z
creators_name: Ballweg, T
creators_name: Casey, C
creators_name: Betthauser, T
creators_name: Zetterberg, H
creators_name: Blennow, K
creators_name: Christian, B
creators_name: Bendlin, BB
creators_name: Johnson, S
creators_name: Sanders, RD
title: Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: EEG, alpha, amyloid, neurodegeneration, tau
note: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
abstract: Electroencephalography signatures of amyloid-β, tau and neurodegenerative pathologies would aid in screening for, tracking progression of, and critically, understanding the pathogenesis of dementia. We hypothesized that slowing of the alpha peak frequency, as a signature of hyperpolarization-activated cyclic nucleotide gated ‘pacemaker’ channel activity, would correlate with amyloid and tau pathology burden measured by amyloid (Pittsburgh Compound B) and tau (MK-6240) positron emission tomography or CSF biomarkers. We also hypothesized that EEG power would be associated with neurodegeneration (CSF neurofilament light and hippocampal volume). Wakeful high-density EEG data were collected from 53 subjects. Both amyloid-β and tau pathology were associated with slowing in the alpha peak frequency [Pittsburgh Compound B (+) vs. Pittsburgh Compound B (−) subjects, P = 0.039 and MK-6240 (+) vs. MK-6240 (−) subjects, P = 0.019]. Furthermore, slowing in the peak alpha frequency correlated with CSF Aβ42/40 ratio (r2 = 0.270; P = 0.003), phosphoTau (pTau181, r2 = 0.290; P = 0.001) and pTau181/Aβ42 (r2 = 0.343; P < 0.001). Alpha peak frequency was not associated with neurodegeneration. Higher CSF neurofilament light was associated with lower total EEG power (r2 = 0.136; P = 0.018), theta power (r2 = 0.148; P = 0.014) and beta power (r2 = 0.216; P = 0.002); the latter was also associated with normalized hippocampal volume (r2 = 0.196; P = 0.002). Amyloid-tau and neurodegenerative pathologies are associated with distinct electrophysiological signatures that may be useful as mechanistic tools and diagnostic/treatment effect biomarkers in clinical trials.
date: 2020-07-15
date_type: published
official_url: https://doi.org/10.1093/braincomms/fcaa099
oa_status: green
full_text_type: pub
pmcid: PMC7475697
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1815884
doi: 10.1093/braincomms/fcaa099
pii: fcaa099
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Brain Communications
volume: 2
number: 2
article_number: fcaa099
event_location: England
citation:        Tanabe, S;    Bo, A;    White, M;    Parker, M;    Farahbakhsh, Z;    Ballweg, T;    Casey, C;                             ... Sanders, RD; + view all <#>        Tanabe, S;  Bo, A;  White, M;  Parker, M;  Farahbakhsh, Z;  Ballweg, T;  Casey, C;  Betthauser, T;  Zetterberg, H;  Blennow, K;  Christian, B;  Bendlin, BB;  Johnson, S;  Sanders, RD;   - view fewer <#>    (2020)    Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology.                   Brain Communications , 2  (2)    , Article fcaa099.  10.1093/braincomms/fcaa099 <https://doi.org/10.1093/braincomms%2Ffcaa099>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10111044/1/fcaa099.pdf