eprintid: 10111044 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/11/10/44 datestamp: 2020-09-30 09:19:46 lastmod: 2021-12-20 00:51:31 status_changed: 2020-09-30 09:19:46 type: article metadata_visibility: show creators_name: Tanabe, S creators_name: Bo, A creators_name: White, M creators_name: Parker, M creators_name: Farahbakhsh, Z creators_name: Ballweg, T creators_name: Casey, C creators_name: Betthauser, T creators_name: Zetterberg, H creators_name: Blennow, K creators_name: Christian, B creators_name: Bendlin, BB creators_name: Johnson, S creators_name: Sanders, RD title: Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: EEG, alpha, amyloid, neurodegeneration, tau note: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com abstract: Electroencephalography signatures of amyloid-β, tau and neurodegenerative pathologies would aid in screening for, tracking progression of, and critically, understanding the pathogenesis of dementia. We hypothesized that slowing of the alpha peak frequency, as a signature of hyperpolarization-activated cyclic nucleotide gated ‘pacemaker’ channel activity, would correlate with amyloid and tau pathology burden measured by amyloid (Pittsburgh Compound B) and tau (MK-6240) positron emission tomography or CSF biomarkers. We also hypothesized that EEG power would be associated with neurodegeneration (CSF neurofilament light and hippocampal volume). Wakeful high-density EEG data were collected from 53 subjects. Both amyloid-β and tau pathology were associated with slowing in the alpha peak frequency [Pittsburgh Compound B (+) vs. Pittsburgh Compound B (−) subjects, P = 0.039 and MK-6240 (+) vs. MK-6240 (−) subjects, P = 0.019]. Furthermore, slowing in the peak alpha frequency correlated with CSF Aβ42/40 ratio (r2 = 0.270; P = 0.003), phosphoTau (pTau181, r2 = 0.290; P = 0.001) and pTau181/Aβ42 (r2 = 0.343; P < 0.001). Alpha peak frequency was not associated with neurodegeneration. Higher CSF neurofilament light was associated with lower total EEG power (r2 = 0.136; P = 0.018), theta power (r2 = 0.148; P = 0.014) and beta power (r2 = 0.216; P = 0.002); the latter was also associated with normalized hippocampal volume (r2 = 0.196; P = 0.002). Amyloid-tau and neurodegenerative pathologies are associated with distinct electrophysiological signatures that may be useful as mechanistic tools and diagnostic/treatment effect biomarkers in clinical trials. date: 2020-07-15 date_type: published official_url: https://doi.org/10.1093/braincomms/fcaa099 oa_status: green full_text_type: pub pmcid: PMC7475697 language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1815884 doi: 10.1093/braincomms/fcaa099 pii: fcaa099 lyricists_name: Zetterberg, Henrik lyricists_id: HZETT94 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Brain Communications volume: 2 number: 2 article_number: fcaa099 event_location: England citation: Tanabe, S; Bo, A; White, M; Parker, M; Farahbakhsh, Z; Ballweg, T; Casey, C; ... Sanders, RD; + view all <#> Tanabe, S; Bo, A; White, M; Parker, M; Farahbakhsh, Z; Ballweg, T; Casey, C; Betthauser, T; Zetterberg, H; Blennow, K; Christian, B; Bendlin, BB; Johnson, S; Sanders, RD; - view fewer <#> (2020) Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology. Brain Communications , 2 (2) , Article fcaa099. 10.1093/braincomms/fcaa099 <https://doi.org/10.1093/braincomms%2Ffcaa099>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10111044/1/fcaa099.pdf