TY - JOUR AV - public IS - 2 KW - EEG KW - alpha KW - amyloid KW - neurodegeneration KW - tau N2 - Electroencephalography signatures of amyloid-?, tau and neurodegenerative pathologies would aid in screening for, tracking progression of, and critically, understanding the pathogenesis of dementia. We hypothesized that slowing of the alpha peak frequency, as a signature of hyperpolarization-activated cyclic nucleotide gated ?pacemaker? channel activity, would correlate with amyloid and tau pathology burden measured by amyloid (Pittsburgh Compound B) and tau (MK-6240) positron emission tomography or CSF biomarkers. We also hypothesized that EEG power would be associated with neurodegeneration (CSF neurofilament light and hippocampal volume). Wakeful high-density EEG data were collected from 53 subjects. Both amyloid-? and tau pathology were associated with slowing in the alpha peak frequency [Pittsburgh Compound B (+) vs. Pittsburgh Compound B (?) subjects, P?=?0.039 and MK-6240 (+) vs. MK-6240 (?) subjects, P?=?0.019]. Furthermore, slowing in the peak alpha frequency correlated with CSF A?42/40 ratio (r2 = 0.270; P?=?0.003), phosphoTau (pTau181, r2 = 0.290; P?=?0.001) and pTau181/A?42 (r2 = 0.343; P?<?0.001). Alpha peak frequency was not associated with neurodegeneration. Higher CSF neurofilament light was associated with lower total EEG power (r2 = 0.136; P?=?0.018), theta power (r2 = 0.148; P?=?0.014) and beta power (r2 = 0.216; P?=?0.002); the latter was also associated with normalized hippocampal volume (r2 = 0.196; P?=?0.002). Amyloid-tau and neurodegenerative pathologies are associated with distinct electrophysiological signatures that may be useful as mechanistic tools and diagnostic/treatment effect biomarkers in clinical trials. A1 - Tanabe, S A1 - Bo, A A1 - White, M A1 - Parker, M A1 - Farahbakhsh, Z A1 - Ballweg, T A1 - Casey, C A1 - Betthauser, T A1 - Zetterberg, H A1 - Blennow, K A1 - Christian, B A1 - Bendlin, BB A1 - Johnson, S A1 - Sanders, RD VL - 2 JF - Brain Communications N1 - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com TI - Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology UR - https://doi.org/10.1093/braincomms/fcaa099 Y1 - 2020/07/15/ ID - discovery10111044 ER -