<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10111044> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/title> "Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/abstract> "Electroencephalography signatures of amyloid-β, tau and neurodegenerative pathologies would aid in screening for, tracking progression of, and critically, understanding the pathogenesis of dementia. We hypothesized that slowing of the alpha peak frequency, as a signature of hyperpolarization-activated cyclic nucleotide gated ‘pacemaker’ channel activity, would correlate with amyloid and tau pathology burden measured by amyloid (Pittsburgh Compound B) and tau (MK-6240) positron emission tomography or CSF biomarkers. We also hypothesized that EEG power would be associated with neurodegeneration (CSF neurofilament light and hippocampal volume). Wakeful high-density EEG data were collected from 53 subjects. Both amyloid-β and tau pathology were associated with slowing in the alpha peak frequency [Pittsburgh Compound B (+) vs. Pittsburgh Compound B (−) subjects, P = 0.039 and MK-6240 (+) vs. MK-6240 (−) subjects, P = 0.019]. Furthermore, slowing in the peak alpha frequency correlated with CSF Aβ42/40 ratio (r2 = 0.270; P = 0.003), phosphoTau (pTau181, r2 = 0.290; P = 0.001) and pTau181/Aβ42 (r2 = 0.343; P < 0.001). Alpha peak frequency was not associated with neurodegeneration. Higher CSF neurofilament light was associated with lower total EEG power (r2 = 0.136; P = 0.018), theta power (r2 = 0.148; P = 0.014) and beta power (r2 = 0.216; P = 0.002); the latter was also associated with normalized hippocampal volume (r2 = 0.196; P = 0.002). Amyloid-tau and neurodegenerative pathologies are associated with distinct electrophysiological signatures that may be useful as mechanistic tools and diagnostic/treatment effect biomarkers in clinical trials."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/date> "2020-07-15" . <https://discovery.ucl.ac.uk/id/document/1183806> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/volume> "2" . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/issue> "2" . <https://discovery.ucl.ac.uk/id/publication/ext-27c78f57f06d32afb0d53250b52b5ef5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-27c78f57f06d32afb0d53250b52b5ef5> <http://xmlns.com/foaf/0.1/name> "Brain Communications"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-27c78f57f06d32afb0d53250b52b5ef5> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-72e2cd22697eb8b36549d8a7443b053a> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-72e2cd22697eb8b36549d8a7443b053a> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b9045182946d37c121c208b651043f2c> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-b9045182946d37c121c208b651043f2c> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cfdc740bf3a0c63210a01a19a80e7767> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-cfdc740bf3a0c63210a01a19a80e7767> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-afd1473a8bbea32e11132b5931627057> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-afd1473a8bbea32e11132b5931627057> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f64f59ebec57efae76d0dd9984bfbaeb> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-f64f59ebec57efae76d0dd9984bfbaeb> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1cfb5f544f1c2e7240b9ad7ca51cf2fa> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-1cfb5f544f1c2e7240b9ad7ca51cf2fa> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> . <https://discovery.ucl.ac.uk/id/eprint/10111044> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> . <https://discovery.ucl.ac.uk/id/eprint/10111044#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> . <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> <http://xmlns.com/foaf/0.1/familyName> "Tanabe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdac6e1f77b600ca664f73163e36ee82> <http://xmlns.com/foaf/0.1/name> "S Tanabe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> <http://xmlns.com/foaf/0.1/familyName> "Casey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11ef931db87b184856eb9bff61955d41> <http://xmlns.com/foaf/0.1/name> "C Casey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> <http://xmlns.com/foaf/0.1/givenName> "Z"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> <http://xmlns.com/foaf/0.1/familyName> "Farahbakhsh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2a18b02d987cc96e4b6248132a847d59> <http://xmlns.com/foaf/0.1/name> "Z Farahbakhsh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> <http://xmlns.com/foaf/0.1/familyName> "Christian"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a21a8e09117ef8628c10d7b7069b7ddd> <http://xmlns.com/foaf/0.1/name> "B Christian"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> <http://xmlns.com/foaf/0.1/givenName> "RD"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> <http://xmlns.com/foaf/0.1/familyName> "Sanders"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f920d6dd64a728e891b5a222c94dacc> <http://xmlns.com/foaf/0.1/name> "RD Sanders"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4d20281ca26fc6f1fb287dfae31e2154> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> <http://xmlns.com/foaf/0.1/familyName> "Betthauser"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f32e0d8fb54a2032eeec94805921f842> <http://xmlns.com/foaf/0.1/name> "T Betthauser"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-239ebb45f9dda6acaed54f370c0126ff> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-cfdc740bf3a0c63210a01a19a80e7767> 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