eprintid: 10110733 rev_number: 17 eprint_status: archive userid: 608 dir: disk0/10/11/07/33 datestamp: 2020-09-25 09:35:58 lastmod: 2021-10-09 22:36:59 status_changed: 2020-09-25 09:35:58 type: article metadata_visibility: show creators_name: Briant, K creators_name: Redlingshöfer, L creators_name: Brodsky, FM title: Clathrin's life beyond 40: Connecting biochemistry with physiology and disease ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: G03 keywords: Clathrin, Clathrin-actin interaction, Clathrin-mediated endocytosis, Clathrin-microtubule interaction, Membrane traffic note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways to differentiation, disease and physiological processes such as glucose metabolism are reviewed. Diversity and commonalities of clathrin pathways across the tree of life reveal species-specific differences enabling functional plasticity in both membrane traffic and cytokinesis. New structural information on clathrin coat formation and cargo interactions emphasises the interplay between clathrin, adaptor proteins, lipids and cargo, and how this interplay regulates quality control of clathrin’s function and is compromised in infection and neurological disease. Roles for balancing clathrin-mediated cargo transport are defined in stem cell development and additional disease states. date: 2020-08 date_type: published official_url: https://doi.org/10.1016/j.ceb.2020.06.004 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1810082 doi: 10.1016/j.ceb.2020.06.004 pii: S0955-0674(20)30091-0 lyricists_name: Briant, Benjamin lyricists_name: Brodsky, Frances lyricists_id: KBRIA65 lyricists_id: FBROD54 actors_name: Brodsky, Frances actors_id: FBROD54 actors_role: owner full_text_status: public publication: Current Opinion in Cell Biology volume: 65 pagerange: 141-149 event_location: England citation: Briant, K; Redlingshöfer, L; Brodsky, FM; (2020) Clathrin's life beyond 40: Connecting biochemistry with physiology and disease. Current Opinion in Cell Biology , 65 pp. 141-149. 10.1016/j.ceb.2020.06.004 <https://doi.org/10.1016/j.ceb.2020.06.004>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10110733/1/Briant-Redlingshoefer-Brodsky-COCEBI.pdf