eprintid: 10110225 rev_number: 18 eprint_status: archive userid: 608 dir: disk0/10/11/02/25 datestamp: 2020-09-17 16:45:27 lastmod: 2021-12-20 00:56:10 status_changed: 2020-09-17 16:45:27 type: article metadata_visibility: show creators_name: Štambuk, J creators_name: Nakić, N creators_name: Vučković, F creators_name: Pučić-Baković, M creators_name: Razdorov, G creators_name: Trbojević-Akmačić, I creators_name: Novokmet, M creators_name: Keser, T creators_name: Vilaj, M creators_name: Štambuk, T creators_name: Gudelj, I creators_name: Šimurina, M creators_name: Song, M creators_name: Wang, H creators_name: Salihović, MP creators_name: Campbell, H creators_name: Rudan, I creators_name: Kolčić, I creators_name: Eller, LA creators_name: McKeigue, P creators_name: Robb, ML creators_name: Halfvarson, J creators_name: Kurtoglu, M creators_name: Annese, V creators_name: Škarić-Jurić, T creators_name: Molokhia, M creators_name: Polašek, O creators_name: Hayward, C creators_name: Kibuuka, H creators_name: Thaqi, K creators_name: Primorac, D creators_name: Gieger, C creators_name: Nitayaphan, S creators_name: Spector, T creators_name: Wang, Y creators_name: Tillin, T creators_name: Chaturvedi, N creators_name: Wilson, JF creators_name: Schanfield, M creators_name: Filipenko, M creators_name: Wang, W creators_name: Lauc, G title: Global variability of the human IgG glycome. ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 divisions: G17 keywords: Fc glycosylation, aging, glycans, immunoglobulin G, mass spectrometry note: © 2020 Štambuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. abstract: Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG's fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age. date: 2020-08-15 date_type: published official_url: https://doi.org/10.18632/aging.103884 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1813393 doi: 10.18632/aging.103884 pii: 103884 lyricists_name: Chaturvedi, Nishi lyricists_name: Tillin, Therese lyricists_id: NCHAT95 lyricists_id: TTILL38 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Aging volume: 12 number: 15 pagerange: 15222-15259 event_location: United States citation: Štambuk, J; Nakić, N; Vučković, F; Pučić-Baković, M; Razdorov, G; Trbojević-Akmačić, I; Novokmet, M; ... Lauc, G; + view all <#> Štambuk, J; Nakić, N; Vučković, F; Pučić-Baković, M; Razdorov, G; Trbojević-Akmačić, I; Novokmet, M; Keser, T; Vilaj, M; Štambuk, T; Gudelj, I; Šimurina, M; Song, M; Wang, H; Salihović, MP; Campbell, H; Rudan, I; Kolčić, I; Eller, LA; McKeigue, P; Robb, ML; Halfvarson, J; Kurtoglu, M; Annese, V; Škarić-Jurić, T; Molokhia, M; Polašek, O; Hayward, C; Kibuuka, H; Thaqi, K; Primorac, D; Gieger, C; Nitayaphan, S; Spector, T; Wang, Y; Tillin, T; Chaturvedi, N; Wilson, JF; Schanfield, M; Filipenko, M; Wang, W; Lauc, G; - view fewer <#> (2020) Global variability of the human IgG glycome. Aging , 12 (15) pp. 15222-15259. 10.18632/aging.103884 <https://doi.org/10.18632/aging.103884>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10110225/1/rp4ifGGniYfNhfT8p.pdf