eprintid: 10109272
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/10/92/72
datestamp: 2020-09-04 14:45:08
lastmod: 2021-11-03 17:39:31
status_changed: 2020-09-04 14:45:08
type: article
metadata_visibility: show
creators_name: Vassileva, K
creators_name: Marsh, M
creators_name: Patel, S
title: Two-pore channels as master regulators of membrane trafficking and endocytic well-being
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
divisions: D77
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to information processing. In this short review, we highlight how molecular and chemical strategies have uncovered multiple roles for TPCs in regulating various aspects of endo-lysosomal trafficking associated with disease. We summarise advances in the identification of new small molecules to pharmacologically target TPCs for medical benefit. Lastly, we discuss possible underpinning molecular mechanism(s) that translate TPC-mediated ionic fluxes to function.
date: 2020-10
date_type: published
official_url: https://doi.org/10.1016/j.cophys.2020.08.002
oa_status: green
full_text_type: other
pmcid: PMC7426208
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1811030
doi: 10.1016/j.cophys.2020.08.002
pii: S2468-8673(20)30085-7
lyricists_name: Marsh, Mark
lyricists_name: Patel, Sandip
lyricists_id: MCPMA80
lyricists_id: SKPAT56
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Current Opinion in Physiology
volume: 17
pagerange: 163-168
event_location: England
citation:        Vassileva, K;    Marsh, M;    Patel, S;      (2020)    Two-pore channels as master regulators of membrane trafficking and endocytic well-being.                   Current Opinion in Physiology , 17    pp. 163-168.    10.1016/j.cophys.2020.08.002 <https://doi.org/10.1016/j.cophys.2020.08.002>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10109272/1/1-s2.0-S2468867320300857-main.pdf