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<https://discovery.ucl.ac.uk/id/eprint/10109247> <http://purl.org/dc/terms/title> "Understanding the association between antidepressants and the risk of being diagnosed with dementia in older people: a self-controlled case series study"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10109247> <http://purl.org/ontology/bibo/abstract> "Background:\r\nGiven concerns about adverse outcomes for older people taking antidepressants in the literature, we investigated whether taking antidepressants elevates the risk of dementia.\r\n\r\nObjective:\r\nThis study aims to investigate the putative association of antidepressants with the risk of dementia.\r\n\r\nMethods:\r\nWe conducted a population-based self-controlled case series analysis of older people with dementia and taking antidepressants, using territory-wide medical records of 194,507 older patients collected by the Hospital Authority of Hong Kong, to investigate the association between antidepressant treatment and the risk of developing dementia in older people.\r\n\r\nResults:\r\nThere was a significantly higher risk of being diagnosed with dementia during the pre-drug-exposed period (incidence rate ratio (IRR) 20.42 (95% CI: 18.66–22.34)) compared to the non-drug-exposed baseline period. The IRR remained high during the drug-exposed period (IRR 8.86 (7.80–10.06)) before returning to a baseline level after washout (IRR 1.12 (0.77–1.36)).\r\n\r\nConclusion:\r\nThe higher risk of dementia before antidepressant treatment may be related to emerging psychiatric symptoms co-occurring with dementia, which trigger medical consultations that result in a decision to begin antidepressants. Our findings do not support a causal relationship between antidepressant treatment and the risk of dementia."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10109247> <http://purl.org/dc/terms/date> "2020-11-10" .
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