<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10109189> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/title> "Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/abstract> "Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition between wake and sleep states with an especially pronounced deficit in initiating rapid eye movement (REM) sleep episodes. The causative mutation, an Ile102Asn substitution in the synaptic vesicular protein, VAMP2, was associated with morphological synaptic changes and specific behavioral deficits, while in vitro electrophysiological investigations with fluorescence imaging revealed a markedly diminished probability of vesicular release in mutants. Our data show that global shifts in the synaptic efficiency across brain-wide networks leads to an altered probability of vigilance state transitions, possibly as a result of an altered excitability balance within local circuits controlling sleep-wake architecture."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/date> "2020-08-12" . <https://discovery.ucl.ac.uk/id/document/1169372> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/volume> "6" . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/issue> "33" . <https://discovery.ucl.ac.uk/id/publication/ext-639928a968e5ec8ffdf40f5d556d7318> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-639928a968e5ec8ffdf40f5d556d7318> <http://xmlns.com/foaf/0.1/name> "Science Advances"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-639928a968e5ec8ffdf40f5d556d7318> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-475ddaa5cb4ffd7470e700415c41887e> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-475ddaa5cb4ffd7470e700415c41887e> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-161c420325a28082af65fdad9160846c> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-161c420325a28082af65fdad9160846c> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1233a55453b216a64361e8c75819453b> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-1233a55453b216a64361e8c75819453b> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2acdf0cb72b3fdb72b7851784db631c7> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-2acdf0cb72b3fdb72b7851784db631c7> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42b03ec1dfe94840087f15ed166b5f23> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-42b03ec1dfe94840087f15ed166b5f23> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ff48c5ece5e7601f3cc6a556d96c6ce5> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ff48c5ece5e7601f3cc6a556d96c6ce5> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-241c01d52fa5e633d79fe083f2c2baa0> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-241c01d52fa5e633d79fe083f2c2baa0> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-21a0b0b630bf2d6a71228507b0327278> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-21a0b0b630bf2d6a71228507b0327278> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d5f5499ecb0050352c1d5e155dd2234f> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-d5f5499ecb0050352c1d5e155dd2234f> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-37fb50a56486ad46eac43fba9b376b6a> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-37fb50a56486ad46eac43fba9b376b6a> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-61057086d4e9b2aa95cb8e22bc9a9375> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-61057086d4e9b2aa95cb8e22bc9a9375> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-48f63f08e18c6eed60bc9ff55c1357d8> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-48f63f08e18c6eed60bc9ff55c1357d8> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7e2b5f6ddbf5db7b68d9d81cbedab385> . <https://discovery.ucl.ac.uk/id/eprint/10109189> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109189#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-7e2b5f6ddbf5db7b68d9d81cbedab385> . <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> <http://xmlns.com/foaf/0.1/familyName> "Yin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ceb524e09524a0c77b71f38dd2708617> <http://xmlns.com/foaf/0.1/name> "M Yin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> <http://xmlns.com/foaf/0.1/givenName> "LA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> <http://xmlns.com/foaf/0.1/familyName> "Brown"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6efe292a6af0bac693ba8579e27e137b> <http://xmlns.com/foaf/0.1/name> "LA Brown"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> <http://xmlns.com/foaf/0.1/familyName> "Heise"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-db410ee71682994e30e910fe9c02f8d6> <http://xmlns.com/foaf/0.1/name> "I Heise"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> <http://xmlns.com/foaf/0.1/familyName> "Bourbia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdb036a45904b9d7020c914dc62ff528> <http://xmlns.com/foaf/0.1/name> "N Bourbia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> <http://xmlns.com/foaf/0.1/familyName> "Lau"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cf616c5cee4be05accadb9d499a479> <http://xmlns.com/foaf/0.1/name> "P Lau"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> <http://xmlns.com/foaf/0.1/givenName> "MR"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> <http://xmlns.com/foaf/0.1/familyName> "Bowl"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f11ff908fdfb25230c31da65203e33ac> <http://xmlns.com/foaf/0.1/name> "MR Bowl"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-42b03ec1dfe94840087f15ed166b5f23> 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