eprintid: 10109145 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/10/91/45 datestamp: 2020-09-02 13:33:42 lastmod: 2021-11-11 17:34:01 status_changed: 2020-09-02 13:33:42 type: article metadata_visibility: show creators_name: Su, CC creators_name: Lai, ECC creators_name: Kao Yang, Y-H creators_name: Man, KKC creators_name: Kubota, K creators_name: Stang, P creators_name: Schuemie, M creators_name: Ryan, P creators_name: Hardy, C creators_name: Zhang, Y creators_name: Kimura, S creators_name: Kamijima, Y creators_name: Wong, ICK creators_name: Setoguchi, S title: Incidence, prevalence and prescription patterns of antipsychotic medications use in Asia and US: A cross-nation comparison with common data model ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G11 keywords: Antipsychotic agents, pharmacoepidemiology note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: The use of antipsychotic medications (APMs) could be different among countries due to availability, approved indications, characteristics and clinical practice. However, there is limited literature providing comparisons of APMs use among countries. To examine trends in antipsychotic prescribing in Taiwan, Hong Kong, Japan, and the United States, we conducted a cross-national study from 2002 to 2014 by using the distributed network approach with common data model. We included all patients who had at least a record of antipsychotic prescription in this study, and defined patients without previous exposure of antipsychotics for 6 months before the index date as new users for incidence estimation. We calculated the incidence, prevalence, and prescription rate of each medication by calendar year. Among older patients, sulpiride was the most incident [incidence rate (IR) 11.0-23.3) and prevalent [prevalence rate (PR) 11.9-14.3) APM in Taiwan, and most prevalent (PR 2.5-3.9) in Japan. Quetiapine and haloperidol were most common in the United States (IR 8.1-9.5; PR 18.0-18.4) and Hong Kong (PR 8.8-13.7; PR 10.6-12.7), respectively. The trend of quetiapine use was increasing in Taiwan, Hong Kong and the United States. As compared to older patients, the younger patients had more propensity to be prescribed second-generation APM for treatment in four countries. Trends in antipsychotic prescribing varied among countries. Quetiapine use was most prevalent in the United States and increasing in Taiwan and Hong Kong. The increasing use of quetiapine in the elderly patients might be due to its safety profile compared to other APMs. date: 2020-12 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.jpsychires.2020.08.025 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1811079 doi: 10.1016/j.jpsychires.2020.08.025 lyricists_name: Man, Keng lyricists_name: Wong, Ian lyricists_id: KCKMA73 lyricists_id: ICKWO00 actors_name: Man, Keng actors_name: Allington-Smith, Dominic actors_id: KCKMA73 actors_id: DAALL44 actors_role: owner actors_role: impersonator full_text_status: public publication: Journal of Psychiatric Research volume: 131 pagerange: 77-84 citation: Su, CC; Lai, ECC; Kao Yang, Y-H; Man, KKC; Kubota, K; Stang, P; Schuemie, M; ... Setoguchi, S; + view all <#> Su, CC; Lai, ECC; Kao Yang, Y-H; Man, KKC; Kubota, K; Stang, P; Schuemie, M; Ryan, P; Hardy, C; Zhang, Y; Kimura, S; Kamijima, Y; Wong, ICK; Setoguchi, S; - view fewer <#> (2020) Incidence, prevalence and prescription patterns of antipsychotic medications use in Asia and US: A cross-nation comparison with common data model. Journal of Psychiatric Research , 131 pp. 77-84. 10.1016/j.jpsychires.2020.08.025 <https://doi.org/10.1016/j.jpsychires.2020.08.025>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10109145/7/Man_1-s2.0-S0022395620309377-main.pdf