<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10109124> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/title> "Gastrointestinal bleeding risk with rivaroxaban vs aspirin in atrial fibrillation: a multinational study"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/abstract> "Purpose:\r\nComparative gastrointestinal bleeding (GIB) risk between rivaroxaban and lowâ€dose aspirin is unknown in patients with atrial fibrillation (AF). This study investigated GIB risk with rivaroxaban vs aspirin among two separate AF cohorts in Hong Kong and the United Kingdom, using a common protocol approach.\r\n\r\nMethods:\r\nThis was a populationâ€based cohort study using separate data from the Clinical Data Analysis and Reporting System (CDARS) of the Hong Kong Hospital Authority (2010â€2018) and The Health Improvement Network (THIN) database in the United Kingdom (2011â€2017). Patients with AF newly prescribed aspirin or rivaroxaban were included. Cox proportional hazards regression was used to compare GIB risks for rivaroxaban vs aspirin, accounting for confounders using propensity score fine stratification approach.\r\n\r\nResults:\r\nIn CDARS, 29 213 patients were included; n = 1052 (rivaroxaban), n = 28 161 (aspirin). Crude GIB event rates per 100 patientâ€years in CDARS were 3.0 (aspirin) and 2.6 (rivaroxaban). No difference in GIB risk was observed between rivaroxaban and aspirin overall (HR = 1.04, 95%CI = 0.76â€1.42), and in doseâ€stratified analyses (HR = 1.21, 95%CI = 0.84â€1.74 [20 mg/day]; HR = 0.80, 95%CI = 0.44â€1.45 [≤15 mg/day]). In THIN, 11 549 patients were included, n = 3496 (rivaroxaban) and n = 8053 (aspirin). Crude GIB event rates were 1.3 (aspirin) and 2.4 (rivaroxaban) per 100 patientâ€years. No difference in GIB risk was observed between rivaroxaban and aspirin overall (HR = 1.40, 95%CI = 1.00â€1.98) and lowâ€dose rivaroxaban (≤15 mg/day) (HR = 1.00, 95%CI = 0.56â€1.30), but increased GIB risk was observed for rivaroxaban 20 mg/day vs aspirin (HR = 1.57, 95%CI = 1.08â€2.29).\r\n\r\nConclusion:\r\nIn patients with AF, GIB risk was comparable between aspirin and rivaroxaban ≤15 mg/day. GIB risk for rivaroxaban 20 mg/day vs aspirin remains uncertain and warrants further investigation."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/date> "2020-12" . <https://discovery.ucl.ac.uk/id/document/1258779> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/volume> "29" . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/issue> "12" . <https://discovery.ucl.ac.uk/id/org/ext-6bea0d1f0ff0b9fb84fc70d587fb237b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-6bea0d1f0ff0b9fb84fc70d587fb237b> <http://xmlns.com/foaf/0.1/name> "John Wiley and Sons"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-6bea0d1f0ff0b9fb84fc70d587fb237b> . <https://discovery.ucl.ac.uk/id/publication/ext-f9d5e2681f9f4bb26b8e686e9ea6479b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-f9d5e2681f9f4bb26b8e686e9ea6479b> <http://xmlns.com/foaf/0.1/name> "Pharmacoepidemiology & Drug Safety"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-f9d5e2681f9f4bb26b8e686e9ea6479b> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-27cdcf072a87f0226ebfc3f76cede96d> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-27cdcf072a87f0226ebfc3f76cede96d> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1e4b06c843c411a4814f9289019728d> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-a1e4b06c843c411a4814f9289019728d> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a193850d7a18782f604eb2b4a0a4f3ad> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a193850d7a18782f604eb2b4a0a4f3ad> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bb4c623f5999ebce6589dbfab80b6d94> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-bb4c623f5999ebce6589dbfab80b6d94> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b10dc8a5399a6d5ab02b620503d079c1> . <https://discovery.ucl.ac.uk/id/eprint/10109124> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> . <https://discovery.ucl.ac.uk/id/eprint/10109124#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-b10dc8a5399a6d5ab02b620503d079c1> . <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> <http://xmlns.com/foaf/0.1/familyName> "Wei"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-29c3cd401fbd113aa304c68a41106c3c> <http://xmlns.com/foaf/0.1/name> "L Wei"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> <http://xmlns.com/foaf/0.1/givenName> "EW"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> <http://xmlns.com/foaf/0.1/familyName> "Chan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-635859384716ce10e29cc244b95fd442> <http://xmlns.com/foaf/0.1/name> "EW Chan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> <http://xmlns.com/foaf/0.1/givenName> "X"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ce7819dc193d710a87bd9e2ba251b3b6> <http://xmlns.com/foaf/0.1/name> "X Li"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> <http://xmlns.com/foaf/0.1/givenName> "JS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> <http://xmlns.com/foaf/0.1/familyName> "Bell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d93dd03643a9fceb8dfb2267fe19c433> <http://xmlns.com/foaf/0.1/name> "JS Bell"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> <http://xmlns.com/foaf/0.1/givenName> "WK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> <http://xmlns.com/foaf/0.1/familyName> "Leung"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-306734eb416fca59af47f7f4dfddd28e> <http://xmlns.com/foaf/0.1/name> "WK Leung"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> <http://xmlns.com/foaf/0.1/familyName> "Fanning"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1e4e82116304c2c8527d983b7e709199> <http://xmlns.com/foaf/0.1/name> "L Fanning"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> <http://xmlns.com/foaf/0.1/givenName> "ICK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> <http://xmlns.com/foaf/0.1/familyName> "Wong"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1238dedc4c5a51094ecd240bcea4c303> <http://xmlns.com/foaf/0.1/name> "ICK Wong"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a193850d7a18782f604eb2b4a0a4f3ad> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a193850d7a18782f604eb2b4a0a4f3ad> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a193850d7a18782f604eb2b4a0a4f3ad> <http://xmlns.com/foaf/0.1/familyName> "Darzins"^^<http://www.w3.org/2001/XMLSchema#string> . 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