eprintid: 10108407
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/10/84/07
datestamp: 2020-08-25 15:02:13
lastmod: 2021-09-17 22:26:03
status_changed: 2020-08-25 15:02:13
type: article
metadata_visibility: show
creators_name: Verhaar, BJH
creators_name: de Leeuw, FA
creators_name: Doorduijn, AS
creators_name: Fieldhouse, JLP
creators_name: van de Rest, O
creators_name: Teunissen, CE
creators_name: van Berckel, BNM
creators_name: Barkhof, F
creators_name: Visser, M
creators_name: de van der Schueren, MAE
creators_name: Scheltens, P
creators_name: Kester, MI
creators_name: Muller, M
creators_name: van der Flier, WM
title: Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F82
keywords: body mass index, cerebral atrophy, fat free mass, fat mass, magnetic resonance imaging, malnutrition, microbleeds, mild cognitive impairment, nutritional status, white matter hyperintensities
note: © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/).
abstract: INTRODUCTION: Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. METHODS: We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. RESULTS: Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. DISCUSSION: Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.
date: 2020
date_type: published
official_url: https://doi.org/10.1002/dad2.12063
oa_status: green
full_text_type: pub
pmcid: PMC7418890
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1808984
doi: 10.1002/dad2.12063
pii: DAD212063
lyricists_name: Barkhof, Frederik
lyricists_id: FBARK32
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
volume: 12
number: 1
article_number: e12063
event_location: United States
issn: 2352-8729
citation:        Verhaar, BJH;    de Leeuw, FA;    Doorduijn, AS;    Fieldhouse, JLP;    van de Rest, O;    Teunissen, CE;    van Berckel, BNM;                             ... van der Flier, WM; + view all <#>        Verhaar, BJH;  de Leeuw, FA;  Doorduijn, AS;  Fieldhouse, JLP;  van de Rest, O;  Teunissen, CE;  van Berckel, BNM;  Barkhof, F;  Visser, M;  de van der Schueren, MAE;  Scheltens, P;  Kester, MI;  Muller, M;  van der Flier, WM;   - view fewer <#>    (2020)    Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project.                   Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 12  (1)    , Article e12063.  10.1002/dad2.12063 <https://doi.org/10.1002/dad2.12063>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10108407/1/dad2.12063.pdf