TY  - JOUR
TI  - Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project
Y1  - 2020///
AV  - public
VL  - 12
N1  - © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution?NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/).
IS  - 1
ID  - discovery10108407
N2  - INTRODUCTION: Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. METHODS: We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. RESULTS: Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. DISCUSSION: Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.
SN  - 2352-8729
UR  - https://doi.org/10.1002/dad2.12063
JF  - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
KW  - body mass index
KW  -  cerebral atrophy
KW  -  fat free mass
KW  -  fat mass
KW  -  magnetic resonance imaging
KW  -  malnutrition
KW  -  microbleeds
KW  -  mild cognitive impairment
KW  -  nutritional status
KW  -  white matter hyperintensities
A1  - Verhaar, BJH
A1  - de Leeuw, FA
A1  - Doorduijn, AS
A1  - Fieldhouse, JLP
A1  - van de Rest, O
A1  - Teunissen, CE
A1  - van Berckel, BNM
A1  - Barkhof, F
A1  - Visser, M
A1  - de van der Schueren, MAE
A1  - Scheltens, P
A1  - Kester, MI
A1  - Muller, M
A1  - van der Flier, WM
ER  -