eprintid: 10108233
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/10/10/82/33
datestamp: 2020-08-21 09:28:11
lastmod: 2021-09-25 23:29:16
status_changed: 2020-08-21 09:28:11
type: article
metadata_visibility: show
creators_name: Chambers, ES
creators_name: Akbar, AN
title: Can blocking inflammation enhance immunity during aging?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G94
keywords: Inflammaging, p38-MAP Kinase, senescence, senolytics
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer with chronic diseases, increased infections, and cancer. A characteristic of aging is the presence of chronic low-grade inflammation that is characterized by elevated concentrations of IL-6, TNF-α, and C-reactive protein, which has been termed inflammaging. Previous studies have demonstrated that chronic inflammation interferes with T-cell response and macrophage function and is also detrimental for vaccine responses. This raises the question of whether therapeutic strategies that reduce inflammation may be useful for improving immunity in older adults. In this review we discuss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity. Finally, we describe existing interventions that target inflammation that have been used to enhance immunity during aging.
date: 2020-05
date_type: published
official_url: https://doi.org/10.1016/j.jaci.2020.03.016
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1781063
doi: 10.1016/j.jaci.2020.03.016
pii: S0091-6749(20)30420-6
lyricists_name: Akbar, Arne
lyricists_id: ANAKB15
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: Journal of Allergy and Clinical Immunology
volume: 145
number: 5
pagerange: 1323-1331
event_location: United States
citation:        Chambers, ES;    Akbar, AN;      (2020)    Can blocking inflammation enhance immunity during aging?                   Journal of Allergy and Clinical Immunology , 145  (5)   pp. 1323-1331.    10.1016/j.jaci.2020.03.016 <https://doi.org/10.1016/j.jaci.2020.03.016>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10108233/3/Akbar_JACI%20review%20280220%20TOP.pdf