TY  - JOUR
IS  - 4
KW  - biomarkers - cerebrospinal fluid - concussion - chronic traumatic encephalopathy - plasma - serum - neurofilament - tau
EP  - 419
SP  - 411
A1  - Shahim, P
A1  - Gill, JM
A1  - Blennow, K
A1  - Zetterberg, H
AV  - public
ID  - discovery10107813
VL  - 40
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
JF  - Seminars in Neurology
TI  - Fluid Biomarkers for Chronic Traumatic Encephalopathy
N2  - Chronic traumatic encephalopathy (CTE) is a neuropathological condition that has been described in individuals who have been exposed to repetitive head impacts, including concussions and subconcussive trauma. Currently, there is no fluid or imaging biomarker for diagnosing CTE during life. Based on retrospective clinical data, symptoms of CTE include changes in behavior, cognition, and mood, and may develop after a latency phase following the injuries. However, these symptoms are often nonspecific, making differential diagnosis based solely on clinical symptoms unreliable. Thus, objective biomarkers for CTE pathophysiology would be helpful in understanding the course of the disease as well as in the development of preventive and therapeutic measures. Herein, we review the literature regarding fluid biomarkers for repetitive concussive and subconcussive head trauma, postconcussive syndrome, as well as potential candidate biomarkers for CTE. We also discuss technical challenges with regard to the current fluid biomarkers and potential pathways to advance the most promising biomarker candidates into clinical routine.
Y1  - 2020/08//
UR  - https://doi.org/10.1055/s-0040-1715095
ER  -