TY - JOUR N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. EP - 3841 AV - public KW - gestation KW - child development KW - offspring KW - pregnancy KW - thyroid KW - neurodevelopmental disorders ID - discovery10107765 VL - 105 PB - Endocrine Society IS - 12 JF - Journal of Clinical Endocrinology and Metabolism UR - https://doi.org/10.1210/clinem/dgaa555 Y1 - 2020/12// A1 - Ge, GM A1 - Leung, MTY A1 - Man, KKC A1 - Leung, WC A1 - Ip, P A1 - Li, GHY A1 - Wong, I A1 - Kung, AWC A1 - Cheung, C-L N2 - Context: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring. Objective: To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring. Data Sources: PubMed, EMBASE, and Cochrane Library. Study Selections: Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children. Data Extraction: Reviewers extracted data on study characteristics and results independently. Data Synthesis: Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies. Results: We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring. Conclusion: Routine measurement and timely treatment on thyroid function should be considered for pregnant women. SP - 3821 TI - Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis ER -