TY  - JOUR
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
EP  - 3841
AV  - public
KW  - gestation
KW  -  child development
KW  -  offspring
KW  -  pregnancy
KW  -  thyroid
KW  -  neurodevelopmental disorders
ID  - discovery10107765
VL  - 105
PB  - Endocrine Society
IS  - 12
JF  - Journal of Clinical Endocrinology and Metabolism
UR  - https://doi.org/10.1210/clinem/dgaa555
Y1  - 2020/12//
A1  - Ge, GM
A1  - Leung, MTY
A1  - Man, KKC
A1  - Leung, WC
A1  - Ip, P
A1  - Li, GHY
A1  - Wong, I
A1  - Kung, AWC
A1  - Cheung, C-L
N2  - Context:
Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring.

Objective:
To review the association between maternal thyroid dysfunction and the risk of adverse outcomes in offspring.

Data Sources:
PubMed, EMBASE, and Cochrane Library.

Study Selections:
Eligible studies reported the association between maternal thyroid hormone function and the risk of adverse outcomes in their children.

Data Extraction:
Reviewers extracted data on study characteristics and results independently.

Data Synthesis:
Estimates were pooled and reported as odds ratio (OR) with 95% confidence interval (CI). I2 tests were applied to assess the heterogeneity across studies.

Results:
We identified 29 eligible articles and found an association between maternal hyperthyroidism and attention deficit hyperactivity disorder (ADHD) (OR: 1.18, 95% CI: 1.04-1.34, I2 = 0%) and epilepsy (OR: 1.19, 95% CI: 1.08-1.31, I2 = 0%) in offspring; as well as an association of maternal hypothyroidism with increased risk of ADHD (OR: 1.14, 95% CI: 1.03-1.26, I2 = 25%), autism spectrum disorder (OR: 1.41, 95% CI: 1.05-1.90, I2 = 63%), and epilepsy (OR: 1.21, 95% CI: 1.06-1.39, I2 = 0%) in offspring.

Conclusion:
Routine measurement and timely treatment on thyroid function should be considered for pregnant women.
SP  - 3821
TI  - Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis
ER  -