eprintid: 10107572
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/10/75/72
datestamp: 2020-08-12 14:31:02
lastmod: 2021-09-19 22:21:18
status_changed: 2020-08-12 14:31:02
type: article
metadata_visibility: show
creators_name: Weigelt, CM
creators_name: Sehgal, R
creators_name: Tain, LS
creators_name: Cheng, J
creators_name: Eßer, J
creators_name: Pahl, A
creators_name: Dieterich, C
creators_name: Grönke, S
creators_name: Partridge, L
title: An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly in the brain and muscle, of diverse long-lived insulin mutants. Strikingly, lifespan extension of insulin mutants is dependent on circSfl, and overexpression of circSfl alone is sufficient to extend the lifespan. Moreover, circSfl is translated into a protein that shares the N terminus and potentially some functions with the full-length Sfl protein encoded by the host gene. Our study demonstrates that insulin signaling affects global circRNA accumulation and reveals an important role of circSfl during aging in vivo.
date: 2020-07-16
date_type: published
official_url: https://doi.org/10.1016/j.molcel.2020.06.011
oa_status: green
full_text_type: pub
pmcid: PMC7318944
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1796657
doi: 10.1016/j.molcel.2020.06.011
pii: S1097-2765(20)30396-8
lyricists_name: Partridge, Linda
lyricists_id: LPART24
actors_name: Partridge, Linda
actors_name: Wright, Michael
actors_id: LPART24
actors_id: MWRIG83
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Molecular Cell
volume: 79
number: 2
pagerange: 268-279.e5
event_location: United States
citation:        Weigelt, CM;    Sehgal, R;    Tain, LS;    Cheng, J;    Eßer, J;    Pahl, A;    Dieterich, C;         ... Partridge, L; + view all <#>        Weigelt, CM;  Sehgal, R;  Tain, LS;  Cheng, J;  Eßer, J;  Pahl, A;  Dieterich, C;  Grönke, S;  Partridge, L;   - view fewer <#>    (2020)    An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila.                   Molecular Cell , 79  (2)   268-279.e5.    10.1016/j.molcel.2020.06.011 <https://doi.org/10.1016/j.molcel.2020.06.011>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10107572/1/main.pdf