<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10107572> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/title> "An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/abstract> "Circular RNAs (circRNAs) are abundant and accumulate with age in neurons of diverse species. However, only few circRNAs have been functionally characterized, and their role during aging has not been addressed. Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly in the brain and muscle, of diverse long-lived insulin mutants. Strikingly, lifespan extension of insulin mutants is dependent on circSfl, and overexpression of circSfl alone is sufficient to extend the lifespan. Moreover, circSfl is translated into a protein that shares the N terminus and potentially some functions with the full-length Sfl protein encoded by the host gene. Our study demonstrates that insulin signaling affects global circRNA accumulation and reveals an important role of circSfl during aging in vivo."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/date> "2020-07-16" .
<https://discovery.ucl.ac.uk/id/document/1158041> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/volume> "79" .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/issue> "2" .
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<https://discovery.ucl.ac.uk/id/publication/ext-bebf9554f2f20d2e3eae8ef2889fa459> <http://xmlns.com/foaf/0.1/name> "Molecular Cell"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dadaa3013428f0d3dab49f33a16cc183> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-357fcb6bf7a4750772eea41f0487b0f2> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0dcfb84617d82b3b9027216a29cc75ce> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10107572#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10107572#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10107572#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> .
<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10107572#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10107572#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> .
<https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> <http://xmlns.com/foaf/0.1/familyName> "Dieterich"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d499a9d1363d9bd12d9c2d5b4c98f3b4> <http://xmlns.com/foaf/0.1/name> "C Dieterich"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ad550b9fb7718ae1db1101bf51af4e8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2ad550b9fb7718ae1db1101bf51af4e8> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ad550b9fb7718ae1db1101bf51af4e8> <http://xmlns.com/foaf/0.1/familyName> "Sehgal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ad550b9fb7718ae1db1101bf51af4e8> <http://xmlns.com/foaf/0.1/name> "R Sehgal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dadaa3013428f0d3dab49f33a16cc183> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dadaa3013428f0d3dab49f33a16cc183> <http://xmlns.com/foaf/0.1/givenName> "LS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dadaa3013428f0d3dab49f33a16cc183> <http://xmlns.com/foaf/0.1/familyName> "Tain"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dadaa3013428f0d3dab49f33a16cc183> <http://xmlns.com/foaf/0.1/name> "LS Tain"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> <http://xmlns.com/foaf/0.1/familyName> "Grönke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba5f02ddf1db4c46196a255be7fe13a> <http://xmlns.com/foaf/0.1/name> "S Grönke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> <http://xmlns.com/foaf/0.1/familyName> "Partridge"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-12a1c0b12a25aed06a2da003d477c009> <http://xmlns.com/foaf/0.1/name> "L Partridge"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> <http://xmlns.com/foaf/0.1/familyName> "Pahl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a6e3ff2e206c4a6a73ea43da9d07736> <http://xmlns.com/foaf/0.1/name> "A Pahl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-357fcb6bf7a4750772eea41f0487b0f2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-357fcb6bf7a4750772eea41f0487b0f2> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-357fcb6bf7a4750772eea41f0487b0f2> <http://xmlns.com/foaf/0.1/familyName> "Cheng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-357fcb6bf7a4750772eea41f0487b0f2> <http://xmlns.com/foaf/0.1/name> "J Cheng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f06aad5d246ec82e515ef1464e5fc375> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f06aad5d246ec82e515ef1464e5fc375> <http://xmlns.com/foaf/0.1/givenName> "CM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f06aad5d246ec82e515ef1464e5fc375> <http://xmlns.com/foaf/0.1/familyName> "Weigelt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f06aad5d246ec82e515ef1464e5fc375> <http://xmlns.com/foaf/0.1/name> "CM Weigelt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0dcfb84617d82b3b9027216a29cc75ce> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0dcfb84617d82b3b9027216a29cc75ce> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0dcfb84617d82b3b9027216a29cc75ce> <http://xmlns.com/foaf/0.1/familyName> "Eßer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0dcfb84617d82b3b9027216a29cc75ce> <http://xmlns.com/foaf/0.1/name> "J Eßer"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10107572> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1158045> .
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