eprintid: 10106500
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/10/65/00
datestamp: 2020-07-31 13:51:25
lastmod: 2022-01-07 23:45:56
status_changed: 2020-07-31 13:51:25
type: article
metadata_visibility: show
creators_name: Shakouri, T
creators_name: Cha, J-R
creators_name: Owji, N
creators_name: Haddow, P
creators_name: Robinson, TE
creators_name: Patel, KD
creators_name: García-Gareta, E
creators_name: Kim, H-W
creators_name: Knowles, JC
title: Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C10
divisions: D21
divisions: H10
divisions: D13
divisions: G22
keywords: 3D Printing, Biomaterials, Bone tissue engineering, Polymer synthesis, Stereolithography
note: This work is licensed under a Creative Commons Attribution 3.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
abstract: Three-dimensional (3D) printing enhances the production of on-demand fabrication of patient-specific devices as well as anatomically fitting implants with high complexity in a cost-effective manner. Additive systems that employ vat photopolymerisation such as stereolithography (SLA) and digital light projection (DLP) are used widely in the field of biomedical science and engineering. However, additive manufacturing methods can be limited by the types of materials that can be used. In this study, we present an isosorbide-based formulation for a polymer resin yielding a range of elastic moduli between 1.73 GN/mm2 dependent on the photoinitiator system used as well as the amount of calcium phosphate filler added. The monomer was prepared and enhanced for 3D-printing using an SLA technique that delivered stable and optimized 3D-printed models. The resin discussed could potentially be used following major surgery for the correction of congenital defects, the removal of oral tumours and the reconstruction of the head and neck region. The surgeon is usually limited with devices available to restore both function and appearance and with the ever-increasing demand for low-priced and efficient facial implants, there is an urgent need to advance new manufacturing approaches and implants with a higher osseointegration performance.
date: 2020-07-16
date_type: published
official_url: https://doi.org/10.1088/1748-605X/aba6d2
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1800357
doi: 10.1088/1748-605X/aba6d2
lyricists_name: Garcia, Elena
lyricists_name: Knowles, Jonathan
lyricists_name: Owji, Nazanin
lyricists_id: EGARC71
lyricists_id: JCKNO52
lyricists_id: NOWJI02
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: Biomedical Materials
event_location: England
citation:        Shakouri, T;    Cha, J-R;    Owji, N;    Haddow, P;    Robinson, TE;    Patel, KD;    García-Gareta, E;         ... Knowles, JC; + view all <#>        Shakouri, T;  Cha, J-R;  Owji, N;  Haddow, P;  Robinson, TE;  Patel, KD;  García-Gareta, E;  Kim, H-W;  Knowles, JC;   - view fewer <#>    (2020)    Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants.                   Biomedical Materials        10.1088/1748-605X/aba6d2 <https://doi.org/10.1088/1748-605X%2Faba6d2>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10106500/1/Knowles_Shakouri%2Bet%2Bal_2020_Biomed._Mater._10.1088_1748-605X_aba6d2.pdf