eprintid: 10106500 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/10/65/00 datestamp: 2020-07-31 13:51:25 lastmod: 2022-01-07 23:45:56 status_changed: 2020-07-31 13:51:25 type: article metadata_visibility: show creators_name: Shakouri, T creators_name: Cha, J-R creators_name: Owji, N creators_name: Haddow, P creators_name: Robinson, TE creators_name: Patel, KD creators_name: García-Gareta, E creators_name: Kim, H-W creators_name: Knowles, JC title: Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D21 divisions: H10 divisions: D13 divisions: G22 keywords: 3D Printing, Biomaterials, Bone tissue engineering, Polymer synthesis, Stereolithography note: This work is licensed under a Creative Commons Attribution 3.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ abstract: Three-dimensional (3D) printing enhances the production of on-demand fabrication of patient-specific devices as well as anatomically fitting implants with high complexity in a cost-effective manner. Additive systems that employ vat photopolymerisation such as stereolithography (SLA) and digital light projection (DLP) are used widely in the field of biomedical science and engineering. However, additive manufacturing methods can be limited by the types of materials that can be used. In this study, we present an isosorbide-based formulation for a polymer resin yielding a range of elastic moduli between 1.73 GN/mm2 dependent on the photoinitiator system used as well as the amount of calcium phosphate filler added. The monomer was prepared and enhanced for 3D-printing using an SLA technique that delivered stable and optimized 3D-printed models. The resin discussed could potentially be used following major surgery for the correction of congenital defects, the removal of oral tumours and the reconstruction of the head and neck region. The surgeon is usually limited with devices available to restore both function and appearance and with the ever-increasing demand for low-priced and efficient facial implants, there is an urgent need to advance new manufacturing approaches and implants with a higher osseointegration performance. date: 2020-07-16 date_type: published official_url: https://doi.org/10.1088/1748-605X/aba6d2 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1800357 doi: 10.1088/1748-605X/aba6d2 lyricists_name: Garcia, Elena lyricists_name: Knowles, Jonathan lyricists_name: Owji, Nazanin lyricists_id: EGARC71 lyricists_id: JCKNO52 lyricists_id: NOWJI02 actors_name: Austen, Jennifer actors_id: JAUST66 actors_role: owner full_text_status: public publication: Biomedical Materials event_location: England citation: Shakouri, T; Cha, J-R; Owji, N; Haddow, P; Robinson, TE; Patel, KD; García-Gareta, E; ... Knowles, JC; + view all <#> Shakouri, T; Cha, J-R; Owji, N; Haddow, P; Robinson, TE; Patel, KD; García-Gareta, E; Kim, H-W; Knowles, JC; - view fewer <#> (2020) Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom- fit hard tissue implants. Biomedical Materials 10.1088/1748-605X/aba6d2 <https://doi.org/10.1088/1748-605X%2Faba6d2>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10106500/1/Knowles_Shakouri%2Bet%2Bal_2020_Biomed._Mater._10.1088_1748-605X_aba6d2.pdf