eprintid: 10106177 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/10/61/77 datestamp: 2020-08-04 14:04:18 lastmod: 2021-10-10 23:18:08 status_changed: 2020-08-04 14:04:18 type: article metadata_visibility: show creators_name: Xiong, X creators_name: Chua, GT creators_name: Chi, S creators_name: Kwan, MYW creators_name: Wong, WHS creators_name: Zhou, A creators_name: Shek, CC creators_name: Tung, KTS creators_name: Qin, H creators_name: Wong, RS creators_name: Li, X creators_name: Chen, P creators_name: Li, S creators_name: Chui, CS creators_name: Tso, WWY creators_name: Ho, MHK creators_name: Wong, ICK creators_name: Chan, GCF creators_name: Lau, YL creators_name: Wong, KKY creators_name: Chung, PHY creators_name: Li, H creators_name: Tam, PKH creators_name: Tang, S-T creators_name: Lp, P title: Haematological and immunological data of Chinese children infected with coronavirus disease 2019 ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G11 keywords: COVID-19, Children, Chinese, Cytokines, Immunoglobulin, Lymphocyte subsets note: This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) abstract: Haematological and immunological data of children with COVID-19 infection is lacking. Between 21st January and 20th March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children’s Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. Their haematological and immunological profiles, including complete blood counts, lymphocyte subsets (T, B and NK cell counts), immunoglobulin (Ig) profiles (IgG, IgA and IgM) and cytokine profiles were analysed and compared between the symptomatic and asymptomatic groups. The median values and the interquartile ranges were calculated. Comparison was made using the Mann–Whitney U test. Children with symptomatic COVID19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels. The obtained data will be utilized for further studies in comparing children and adults with COVID-19 infections in other parts of the world and with different severity . date: 2020-08 date_type: published official_url: https://doi.org/10.1016/j.dib.2020.105953 oa_status: green full_text_type: pub pmcid: PMC7324312 language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1799076 doi: 10.1016/j.dib.2020.105953 pii: 105953 lyricists_name: Wong, Ian lyricists_id: ICKWO00 actors_name: Wong, Ian actors_name: Harris, Jean actors_id: ICKWO00 actors_id: JAHAR68 actors_role: owner actors_role: impersonator full_text_status: public publication: Data Brief volume: 31 article_number: 105953 event_location: Netherlands citation: Xiong, X; Chua, GT; Chi, S; Kwan, MYW; Wong, WHS; Zhou, A; Shek, CC; ... Lp, P; + view all <#> Xiong, X; Chua, GT; Chi, S; Kwan, MYW; Wong, WHS; Zhou, A; Shek, CC; Tung, KTS; Qin, H; Wong, RS; Li, X; Chen, P; Li, S; Chui, CS; Tso, WWY; Ho, MHK; Wong, ICK; Chan, GCF; Lau, YL; Wong, KKY; Chung, PHY; Li, H; Tam, PKH; Tang, S-T; Lp, P; - view fewer <#> (2020) Haematological and immunological data of Chinese children infected with coronavirus disease 2019. Data Brief , 31 , Article 105953. 10.1016/j.dib.2020.105953 <https://doi.org/10.1016/j.dib.2020.105953>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10106177/1/1-s2.0-S2352340920308477-main.pdf