eprintid: 10106068 rev_number: 16 eprint_status: archive userid: 608 dir: disk0/10/10/60/68 datestamp: 2020-07-23 21:46:55 lastmod: 2021-09-26 23:16:25 status_changed: 2020-07-23 21:46:55 type: article metadata_visibility: show creators_name: Angelova, PR creators_name: Esteras, N creators_name: Abramov, AY title: Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 keywords: Nrf2, PUFAs, ROS, free radicals, lipid peroxidation, mitochondria, neurodegeneration note: © 2020 The Authors. Medicinal Research Reviews Published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: The world's population aging progression renders age-related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite the progress in studying the development of pathology, finding ways for modifying neurodegenerative disorders remains a high priority. One common feature of neurodegenerative diseases is mitochondrial dysfunction and overproduction of reactive oxygen species, resulting in oxidative stress. Although lipid peroxidation is one of the markers for oxidative stress, it also plays an important role in cell physiology, including activation of phospholipases and stimulation of signaling cascades. Excessive lipid peroxidation is a hallmark for most neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and many other neurological conditions. The products of lipid peroxidation have been shown to be the trigger for necrotic, apoptotic, and more specifically for oxidative stress-related, that is, ferroptosis and neuronal cell death. Here we discuss the involvement of lipid peroxidation in the mechanism of neuronal loss and some novel therapeutic directions to oppose it. date: 2020-07-13 date_type: published official_url: https://doi.org/10.1002/med.21712 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1798271 doi: 10.1002/med.21712 lyricists_name: Abramov, Andrey lyricists_name: Esteras Gallego, Noemi lyricists_name: Stroh, Plamena lyricists_id: AABRA58 lyricists_id: NESTE12 lyricists_id: PSTRO69 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: Medicinal Research Reviews event_location: United States citation: Angelova, PR; Esteras, N; Abramov, AY; (2020) Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention. Medicinal Research Reviews 10.1002/med.21712 <https://doi.org/10.1002/med.21712>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10106068/1/Abramov_Mitochondria%20and%20lipid%20peroxidation%20in%20the%20mechanism%20of%20neurodegeneration-%20Finding%20ways%20for%20prevention_AOP.pdf