eprintid: 10106068
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/10/60/68
datestamp: 2020-07-23 21:46:55
lastmod: 2021-09-26 23:16:25
status_changed: 2020-07-23 21:46:55
type: article
metadata_visibility: show
creators_name: Angelova, PR
creators_name: Esteras, N
creators_name: Abramov, AY
title: Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Nrf2, PUFAs, ROS, free radicals, lipid peroxidation, mitochondria, neurodegeneration
note: © 2020 The Authors. Medicinal Research Reviews Published by Wiley Periodicals LLC

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: The world's population aging progression renders age-related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite the progress in studying the development of pathology, finding ways for modifying neurodegenerative disorders remains a high priority. One common feature of neurodegenerative diseases is mitochondrial dysfunction and overproduction of reactive oxygen species, resulting in oxidative stress. Although lipid peroxidation is one of the markers for oxidative stress, it also plays an important role in cell physiology, including activation of phospholipases and stimulation of signaling cascades. Excessive lipid peroxidation is a hallmark for most neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and many other neurological conditions. The products of lipid peroxidation have been shown to be the trigger for necrotic, apoptotic, and more specifically for oxidative stress-related, that is, ferroptosis and neuronal cell death. Here we discuss the involvement of lipid peroxidation in the mechanism of neuronal loss and some novel therapeutic directions to oppose it.
date: 2020-07-13
date_type: published
official_url: https://doi.org/10.1002/med.21712
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1798271
doi: 10.1002/med.21712
lyricists_name: Abramov, Andrey
lyricists_name: Esteras Gallego, Noemi
lyricists_name: Stroh, Plamena
lyricists_id: AABRA58
lyricists_id: NESTE12
lyricists_id: PSTRO69
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Medicinal Research Reviews
event_location: United States
citation:        Angelova, PR;    Esteras, N;    Abramov, AY;      (2020)    Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention.                   Medicinal Research Reviews        10.1002/med.21712 <https://doi.org/10.1002/med.21712>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10106068/1/Abramov_Mitochondria%20and%20lipid%20peroxidation%20in%20the%20mechanism%20of%20neurodegeneration-%20Finding%20ways%20for%20prevention_AOP.pdf