<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10106001> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/title> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/abstract> "Downregulation of BST-2/tetherin and CD4 by HIV-1 viral protein U (Vpu) promotes viral egress and allows infected cells to evade host immunity. Little is known however about the natural variability in these Vpu functions among the genetically diverse viral subtypes that contribute to the HIV-1 pandemic. We collected Vpu isolates from 332 treatment-naive individuals living with chronic HIV-1 infection in Uganda, Rwanda, South Africa, and Canada. Together, these Vpu isolates represent four major HIV-1 group M subtypes (A [n = 63], B [n = 84], C [n = 94], and D [n = 59]) plus intersubtype recombinants and uncommon strains (n = 32). The ability of each Vpu clone to downregulate endogenous CD4 and tetherin was quantified using flow cytometry following transfection into an immortalized T-cell line and compared to that of a reference Vpu clone derived from HIV-1 subtype B NL4.3. Overall, the median CD4 downregulation function of natural Vpu isolates was similar to that of NL4.3 (1.01 [interquartile range {IQR}, 0.86 to 1.18]), while the median tetherin downregulation function was moderately lower than that of NL4.3 (0.90 [0.79 to 0.97]). Both Vpu functions varied significantly among HIV-1 subtypes (Kruskal-Wallis P < 0.0001). Specifically, subtype C clones exhibited the lowest CD4 and tetherin downregulation activities, while subtype D and B clones were most functional for both activities. We also identified Vpu polymorphisms associated with CD4 or tetherin downregulation function and validated six of these using site-directed mutagenesis. Our results highlight the marked extent to which Vpu function varies among global HIV-1 strains, raising the possibility that natural variation in this accessory protein may contribute to viral pathogenesis and/or spread.IMPORTANCE The HIV-1 accessory protein Vpu enhances viral spread by downregulating CD4 and BST-2/tetherin on the surface of infected cells. Natural variability in these Vpu functions may contribute to HIV-1 pathogenesis, but this has not been investigated among the diverse viral subtypes that contribute to the HIV-1 pandemic. In this study, we found that Vpu function differs significantly among HIV-1 subtypes A, B, C, and D. On average, subtype C clones displayed the lowest ability to downregulate both CD4 and tetherin, while subtype B and D clones were more functional. We also identified Vpu polymorphisms that associate with functional differences among HIV-1 isolates and subtypes. Our study suggests that genetic diversity in Vpu may play an important role in the differential pathogenesis and/or spread of HIV-1."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/date> "2020-07-01" .
<https://discovery.ucl.ac.uk/id/document/1147513> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/volume> "94" .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/issue> "14" .
<https://discovery.ucl.ac.uk/id/publication/ext-2add5c9b87f346bcc00e5afb62077bb3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-2add5c9b87f346bcc00e5afb62077bb3> <http://xmlns.com/foaf/0.1/name> "Journal of Virology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-2add5c9b87f346bcc00e5afb62077bb3> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10106001#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10106001#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> .
<https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> <http://xmlns.com/foaf/0.1/familyName> "Hunter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f059903e0284511f70e2d781b971f344> <http://xmlns.com/foaf/0.1/name> "E Hunter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> <http://xmlns.com/foaf/0.1/familyName> "Chandrarathna"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c66c40127744933b4758af4be6370d7> <http://xmlns.com/foaf/0.1/name> "S Chandrarathna"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> <http://xmlns.com/foaf/0.1/givenName> "ZL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> <http://xmlns.com/foaf/0.1/familyName> "Brumme"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2811e2620fcf450577cf94be0829ed30> <http://xmlns.com/foaf/0.1/name> "ZL Brumme"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> <http://xmlns.com/foaf/0.1/familyName> "Muzoora"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d22205fc08e1da754f54a122d2399ca1> <http://xmlns.com/foaf/0.1/name> "C Muzoora"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> <http://xmlns.com/foaf/0.1/givenName> "PW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> <http://xmlns.com/foaf/0.1/familyName> "Hunt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d75364ab86a9b4eca02eeac80aa39f68> <http://xmlns.com/foaf/0.1/name> "PW Hunt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> <http://xmlns.com/foaf/0.1/givenName> "CJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> <http://xmlns.com/foaf/0.1/familyName> "Brumme"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-da31e6cc22e4d9352fc98d0798fc25e6> <http://xmlns.com/foaf/0.1/name> "CJ Brumme"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> <http://xmlns.com/foaf/0.1/givenName> "MA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> <http://xmlns.com/foaf/0.1/familyName> "Brockman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-805a221b3fb6466a37c2565eef9731c8> <http://xmlns.com/foaf/0.1/name> "MA Brockman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> <http://xmlns.com/foaf/0.1/givenName> "GQ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e267816c5c98d5284107ae52bb9c0c63> <http://xmlns.com/foaf/0.1/name> "GQ Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> <http://xmlns.com/foaf/0.1/familyName> "Allen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31ee7cce8348f8b6afd87cbdc5837f74> <http://xmlns.com/foaf/0.1/name> "S Allen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> <http://xmlns.com/foaf/0.1/givenName> "DR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> <http://xmlns.com/foaf/0.1/familyName> "Bangsberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842477c7d5064b38ce7e0175d92f736d> <http://xmlns.com/foaf/0.1/name> "DR Bangsberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> <http://xmlns.com/foaf/0.1/familyName> "Byakwaga"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564c93c0f637173c27a55614f8361e0c> <http://xmlns.com/foaf/0.1/name> "H Byakwaga"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> <http://xmlns.com/foaf/0.1/familyName> "Ndung'u"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e91d047c54db4baa35aba3c13ff442c0> <http://xmlns.com/foaf/0.1/name> "T Ndung'u"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> <http://xmlns.com/foaf/0.1/familyName> "Reddy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ed6d444ee0ceb231d0c52672fafd9af> <http://xmlns.com/foaf/0.1/name> "N Reddy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> <http://xmlns.com/foaf/0.1/familyName> "Umviligihozo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c928fbc14eb54f8c534ee89cc7fe3bc> <http://xmlns.com/foaf/0.1/name> "G Umviligihozo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> <http://xmlns.com/foaf/0.1/givenName> "JN"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> <http://xmlns.com/foaf/0.1/familyName> "Martin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-126809c56d1c853b3fbf554507d7654c> <http://xmlns.com/foaf/0.1/name> "JN Martin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> <http://xmlns.com/foaf/0.1/givenName> "SW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> <http://xmlns.com/foaf/0.1/familyName> "Jin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d407a275eb6fd0a036f92578255151cb> <http://xmlns.com/foaf/0.1/name> "SW Jin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> <http://xmlns.com/foaf/0.1/givenName> "KD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> <http://xmlns.com/foaf/0.1/familyName> "Cobarrubias"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b44b1a9db03cac5165fcf5f6e9c9b474> <http://xmlns.com/foaf/0.1/name> "KD Cobarrubias"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> <http://xmlns.com/foaf/0.1/familyName> "Karita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-93efefd08b08367e844fc4cb72a5cb99> <http://xmlns.com/foaf/0.1/name> "E Karita"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> <http://xmlns.com/foaf/0.1/givenName> "MB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> <http://xmlns.com/foaf/0.1/familyName> "Bwana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16718efd2c759aca0274ae643ff5de59> <http://xmlns.com/foaf/0.1/name> "MB Bwana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147513> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147513> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147513> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/1/Journal%20of%20Virology-2020-Umviligihozo-e00293-20.full.pdf> .
<https://discovery.ucl.ac.uk/id/document/1147513> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/1/Journal%20of%20Virology-2020-Umviligihozo-e00293-20.full.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/1/Journal%20of%20Virology-2020-Umviligihozo-e00293-20.full.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "Journal of Virology-2020-Umviligihozo-e00293-20.full.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147515> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/document/1147515> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/2/lightbox.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "lightbox.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147516> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/document/1147516> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/3/preview.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "preview.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147517> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/document/1147517> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/4/medium.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "medium.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147518> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/document/1147518> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/5/small.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "small.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1147519> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://www.w3.org/2000/01/rdf-schema#label> "Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/1147513> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10106001/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/1147519> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10106001/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/6/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10106001> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/10106001/> .
<https://discovery.ucl.ac.uk/id/eprint/10106001/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10106001 \n\nDifferential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/10106001/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/10106001/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10106001> .