TY  - UNPB
M1  - Doctoral
A1  - Jones, James Francis Xavier
PB  - UCL (University College London)
Y1  - 1994///
N2  - This thesis explores the central organization of the reflex associated with pulmonary C-fibre stimulation. In particular the circulatory and respiratory changes associated with the pulmonary chemoreflex are analyzed. Electrophysiological techniques are used to dissect the medullary networks involved in elaborating the cardiac vagal changes that occur in response to phenylbiguanide administered into the pulmonary circulation. The primary objective is to explain why the cardioinhibition of the pulmonary chemoreflex is unaffected by central respiratory activity. Results from experiments performed on cat, rat, rabbit and dogfish are described. Two different populations of cardiac vagal preganglionic neurones are described in the cat. One population displays respiratory related activity and the other, tonic non- respiratory related activity. Both populations are implicated in the pulmonary chemoreflex. The results of vagal stimulation experiments, performed with anodal block, demonstrate that both populations of cardiac vagal preganglionic neurones have chronotropic action in the cat, rat and rabbit. A hypothesis, based on the existence of two populations of cardioinhibitory vagal preganglionic neurones, is advanced to interpret certain features of the vagal control of the heart which hitherto, have eluded explanation. A philosophy is presented that endeavours to examine the possible evolutionary physiology of such a system.
AV  - public
EP  - 210
N1  - Thesis digitised by ProQuest.
ID  - discovery10105961
TI  - The central control of the pulmonary chemoreflex
KW  - Biological sciences; Pulmonary chemoreflex
UR  - https://discovery.ucl.ac.uk/id/eprint/10105961/
ER  -