eprintid: 10105385 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/10/53/85 datestamp: 2020-07-17 15:40:24 lastmod: 2021-09-20 22:32:33 status_changed: 2020-07-17 15:40:24 type: article metadata_visibility: show creators_name: Jerjian, SJ creators_name: Sahani, M creators_name: Kraskov, A title: Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 divisions: C08 divisions: D76 note: This is an Open Acces article published under a Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). abstract: Pyramidal tract neurons (PTNs) within macaque rostral ventral premotor cortex (F5) and primary motor cortex (M1) provide direct input to spinal circuitry and are critical for skilled movement control. Contrary to initial hypotheses, they can also be active during action observation, in the absence of any movement. A population-level understanding of this phenomenon is currently lacking. We recorded from single neurons, including identified PTNs, in M1 (n=187), and area F5 (n=115) as two adult male macaques executed, observed, or withheld (NoGo) reach-to-grasp actions. F5 maintained a similar representation of grasping actions during both execution and observation. In contrast, although many individual M1 neurons were active during observation, M1 population activity was distinct from execution, and more closely aligned to NoGo activity, suggesting this activity contributes to withholding of self-movement. M1 and its outputs may dissociate the initiation of movement from the representation of grasp in order to flexibly guide behaviour. date: 2020-07-06 date_type: published official_url: https://doi.org/10.7554/eLife.54139 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1796846 doi: 10.7554/eLife.54139 pii: 54139 lyricists_name: Kraskov, Alexander lyricists_name: Sahani, Maneesh lyricists_id: AKRAS80 lyricists_id: MSAHA91 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: eLife volume: 9 article_number: e54139 event_location: England citation: Jerjian, SJ; Sahani, M; Kraskov, A; (2020) Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons. eLife , 9 , Article e54139. 10.7554/eLife.54139 <https://doi.org/10.7554/eLife.54139>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10105385/1/elife-54139-v1.pdf