@article{discovery10105363,
            year = {2020},
           title = {Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli},
         journal = {Evidence-Based Complementary and Alternative Medicine},
          volume = {2020},
            note = {Copyright {\copyright} 2020 Awo Afi Kwapong et al. *is is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.},
             url = {http://dx.doi.org/10.1155/2020/1604638},
        abstract = {Hexane extract and methanol fraction from the stem bark of Myristica lowiana specifically and significantly inhibited the conjugal transfer of the IncW plasmid R7K, a plasmid which harbors ampicillin-, streptomycin-, and spectinomycin-resistant genes. The transfer of this plasmid via the conjugative pilli of Escherichia coli was reduced by 76.5 {$\pm$} 2.0\% and 79.0 {$\pm$} 1.2\% by hexane extract and methanol fraction of M. lowiana, respectively. The hexane extract exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells. The hexane extract and methanol fraction were screened using phytochemical tests, NMR spectroscopy, IR spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS) and were found to contain terpenoids, sterols, and fatty acids.},
            issn = {1741-427X},
          author = {Kwapong, AA and Soares, S and Teo, SP and Stapleton, P and Gibbons, S}
}