<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10104967> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/title> "Antiâ€dopamine D2 receptor antibodies in chronic tic disorders"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/abstract> "AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/date> "2020-10" . <https://discovery.ucl.ac.uk/id/document/1143568> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/volume> "62" . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/issue> "10" . <https://discovery.ucl.ac.uk/id/publication/ext-5ee0310eeef5593330c1a7b13dde51dc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-5ee0310eeef5593330c1a7b13dde51dc> <http://xmlns.com/foaf/0.1/name> "Developmental Medicine & Child Neurology"^^<http://www.w3.org/2001/XMLSchema#string> . 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<https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> . <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-89b33b51c61c5bba44671b55bda0648d> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> . <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> . <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> . <https://discovery.ucl.ac.uk/id/eprint/10104967#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> . <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> <http://xmlns.com/foaf/0.1/familyName> "Buttiglione"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-47e3b47d884194d1aff72797f5fb65c6> <http://xmlns.com/foaf/0.1/name> "M Buttiglione"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> <http://xmlns.com/foaf/0.1/givenName> ""^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> <http://xmlns.com/foaf/0.1/familyName> "Emtics Collaborative Group"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a7e40333669a642793e447a2de32498d> <http://xmlns.com/foaf/0.1/name> " Emtics Collaborative Group"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-238acc7e4249abcdd8ec91c61896a12b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-238acc7e4249abcdd8ec91c61896a12b> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-238acc7e4249abcdd8ec91c61896a12b> <http://xmlns.com/foaf/0.1/familyName> "Baglioni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-238acc7e4249abcdd8ec91c61896a12b> <http://xmlns.com/foaf/0.1/name> "V Baglioni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49f9e7a8b88a8c184ac91255ee1ab86b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-49f9e7a8b88a8c184ac91255ee1ab86b> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49f9e7a8b88a8c184ac91255ee1ab86b> <http://xmlns.com/foaf/0.1/familyName> "Addabbo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49f9e7a8b88a8c184ac91255ee1ab86b> <http://xmlns.com/foaf/0.1/name> "F Addabbo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3a1395f63e00511d321daad2411dd950> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3a1395f63e00511d321daad2411dd950> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3a1395f63e00511d321daad2411dd950> <http://xmlns.com/foaf/0.1/familyName> "Schrag"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3a1395f63e00511d321daad2411dd950> <http://xmlns.com/foaf/0.1/name> "A Schrag"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> <http://xmlns.com/foaf/0.1/familyName> "Martino"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-043066c0bf1d951a35ef82d160c71bdb> <http://xmlns.com/foaf/0.1/name> "D Martino"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38c9c0bf0ffdb722a464a50375eed9b5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-38c9c0bf0ffdb722a464a50375eed9b5> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38c9c0bf0ffdb722a464a50375eed9b5> <http://xmlns.com/foaf/0.1/familyName> "Dietrich"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-38c9c0bf0ffdb722a464a50375eed9b5> <http://xmlns.com/foaf/0.1/name> "A Dietrich"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-89b33b51c61c5bba44671b55bda0648d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-89b33b51c61c5bba44671b55bda0648d> <http://xmlns.com/foaf/0.1/givenName> "PJ"^^<http://www.w3.org/2001/XMLSchema#string> . 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Schwarz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10104967> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1143568> . <https://discovery.ucl.ac.uk/id/document/1143568> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1143568> <http://www.w3.org/2000/01/rdf-schema#label> "Antiâ€dopamine D2 receptor antibodies in chronic tic disorders (Text)"^^<http://www.w3.org/2001/XMLSchema#string> . 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