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<https://discovery.ucl.ac.uk/id/eprint/10103547> <http://purl.org/dc/terms/title> "RGS4 controls secretion of von Willebrand factor to the subendothelial matrix"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10103547> <http://purl.org/ontology/bibo/abstract> "The haemostatic protein von Willebrand Factor (VWF) exists in plasma and subendothelial pools; the\r\nformer secreted from endothelial storage granules, Weibel-Palade bodies (WPBs), by basal secretion\r\nwith a contribution from agonist-stimulated secretion, the latter secreted into the subendothelial\r\nmatrix by a constitutive pathway, not involving WPBs. We set out to determine if the constitutive\r\nrelease of subendothelial VWF is actually regulated and if so, what functional consequences this might\r\nhave.\r\nConstitutive VWF secretion can be increased by a range of factors; changes in VWF expression, levels\r\nof TNF-alpha or other environmental cues. An RNAseq analysis revealed that expression of RGS4\r\n(Regulator of G protein signalling 4) was reduced in endothelial cells (HUVECs) grown under these\r\nconditions. si-RGS4 treatment of HUVECs increased constitutive basolateral secretion of VWF,\r\nprobably by affecting the anterograde secretory pathway. In a simple model of endothelial damage\r\nwe show that RGS4-silenced cells increased platelet recruitment onto the subendothelial matrix under\r\nflow. These results show that changes in RGS4 expression alter levels of subendothelial VWF, affecting\r\nplatelet recruitment. This introduces a novel control over VWF function."^^<http://www.w3.org/2001/XMLSchema#string> .
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