eprintid: 10101739
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/10/17/39
datestamp: 2020-06-22 15:46:32
lastmod: 2021-10-05 00:51:04
status_changed: 2020-06-22 15:46:32
type: article
metadata_visibility: show
creators_name: Yue, L
creators_name: Iannetti, GD
creators_name: Hu, L
title: The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
keywords: biomarkers, gamma-band oscillations, interneurons, pain, primary motor cortex, primary somatosensory cortex
note: Copyright © 2020 Yue et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
abstract: Gamma-band oscillations (GBOs) elicited by transient nociceptive stimuli are one of the most promising biomarkers of pain across species. Still, whether these GBOs reflect stimulus encoding in the primary somatosensory cortex (S1) or nocifensive behavior in the primary motor cortex (M1) is debated. Here we recorded neural activity simultaneously from the brain surface as well as at different depths of the bilateral S1/M1 in freely-moving male rats receiving nociceptive stimulation. GBOs measured from superficial layers of S1 contralateral to the stimulated paw not only had the largest magnitude, but also showed the strongest temporal and phase coupling with epidural GBOs. Also, spiking of superficial S1 interneurons had the strongest phase coherence with epidural GBOs. These results provide the first direct demonstration that scalp GBOs, one of the most promising pain biomarkers, reflect neural activity strongly coupled with the fast spiking of interneurons in the superficial layers of the S1 contralateral to the stimulated side.
date: 2020-04-22
date_type: published
publisher: SOC NEUROSCIENCE
official_url: https://doi.org/10.1523/JNEUROSCI.0255-20.2020
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1775724
doi: 10.1523/JNEUROSCI.0255-20.2020
lyricists_name: Iannetti, Giandomenico
lyricists_id: GDIAN90
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: The Journal of Neuroscience
volume: 40
number: 17
pagerange: 3478-3490
pages: 13
citation:        Yue, L;    Iannetti, GD;    Hu, L;      (2020)    The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations.                   The Journal of Neuroscience , 40  (17)   pp. 3478-3490.    10.1523/JNEUROSCI.0255-20.2020 <https://doi.org/10.1523/JNEUROSCI.0255-20.2020>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10101739/1/3478.full.pdf