eprintid: 10099534
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/09/95/34
datestamp: 2020-06-04 09:41:45
lastmod: 2021-09-25 22:56:15
status_changed: 2020-07-20 11:23:12
type: article
metadata_visibility: show
creators_name: Gould, GW
creators_name: Brodsky, F
creators_name: Bryant, NJ
title: Building GLUT4 vesilces: CHC22 clathrin's human touch
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G03
keywords: GLUT4, insulin, CHC22 clathrin, ERGIC, membrane trafficking, diabetes
note: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent cells have been invaluable in understanding GLUT4 traffic, evolutionary plasticity must be considered when extrapolating these findings to humans. Recent work has identified species-specific distinctions in GLUT4 traffic, notably the participation of a novel clathrin isoform, CHC22, in humans but not rodents. Here, we discuss GLUT4 sorting in different species and how studies of CHC22 have identified new routes for GLUT4 trafficking. We further consider how different sorting-protein complexes relate to these routes and discuss other implications of these pathways in cell biology and disease.
date: 2020-06-30
date_type: published
publisher: Elsevier
official_url: https://doi.org/10.1016/j.tcb.2020.05.007
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1787417
doi: 10.1016/j.tcb.2020.05.007
lyricists_name: Brodsky, Frances
lyricists_id: FBROD54
actors_name: Dewerpe, Marie
actors_id: MDDEW97
actors_role: owner
full_text_status: public
publication: Trends in Cell Biology
issn: 0962-8924
citation:        Gould, GW;    Brodsky, F;    Bryant, NJ;      (2020)    Building GLUT4 vesilces: CHC22 clathrin's human touch.                   Trends in Cell Biology        10.1016/j.tcb.2020.05.007 <https://doi.org/10.1016/j.tcb.2020.05.007>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10099534/7/Brodsky_1-s2.0-S0962892420301045-main%20%281%29.pdf