eprintid: 10099182
rev_number: 15
eprint_status: archive
userid: 608
dir: disk0/10/09/91/82
datestamp: 2020-06-01 11:18:46
lastmod: 2021-10-03 23:57:48
status_changed: 2020-06-01 11:18:46
type: article
metadata_visibility: show
creators_name: Emmanouilidou, E
creators_name: Papagiannakis, N
creators_name: Kouloulia, S
creators_name: Galaziou, A
creators_name: Antonellou, R
creators_name: Papadimitriou, D
creators_name: Athanasiadou, A
creators_name: Bozi, M
creators_name: Koros, C
creators_name: Maniati, M
creators_name: Vekrellis, K
creators_name: Ioannou, PC
creators_name: Stefanis, L
title: Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
keywords: A53T, Alpha-synuclein, Parkinson disease, Plasma, Serum
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: BACKGROUND: Variations of α-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients. METHODS: Serum and plasma were obtained from PD patients without known mutations (GU-PD, n = 124)), carriers of the A53T/G209A point mutation in the α-synuclein gene (SNCA) (n = 29), and respective age-/sex-matched controls. Levels of total α-synuclein were assessed using an in-house ELISA assay. RESULTS: A statistically significant increase of α-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of α-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma α-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients. CONCLUSION: Increased α-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of α-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of α-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele.
date: 2020-04
date_type: published
official_url: https://doi.org/10.1016/j.parkreldis.2020.03.014
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1776571
doi: 10.1016/j.parkreldis.2020.03.014
pii: S1353-8020(20)30070-5
lyricists_name: Kouloulia, Stella
lyricists_id: SKOUL07
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Parkinsonism & Related Disorders
volume: 73
pagerange: 35-40
event_location: England
citation:        Emmanouilidou, E;    Papagiannakis, N;    Kouloulia, S;    Galaziou, A;    Antonellou, R;    Papadimitriou, D;    Athanasiadou, A;                         ... Stefanis, L; + view all <#>        Emmanouilidou, E;  Papagiannakis, N;  Kouloulia, S;  Galaziou, A;  Antonellou, R;  Papadimitriou, D;  Athanasiadou, A;  Bozi, M;  Koros, C;  Maniati, M;  Vekrellis, K;  Ioannou, PC;  Stefanis, L;   - view fewer <#>    (2020)    Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease.                   Parkinsonism & Related Disorders , 73    pp. 35-40.    10.1016/j.parkreldis.2020.03.014 <https://doi.org/10.1016/j.parkreldis.2020.03.014>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10099182/1/Kouloulia_Peripheral%20alpha-synuclein%20levels%20in%20patients%20with%20genetic%20and%20non-genetic%20forms%20of%20Parkinson%27s%20disease_AAM.pdf