<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10099182> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/title> "Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Variations of α-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients. METHODS: Serum and plasma were obtained from PD patients without known mutations (GU-PD, n = 124)), carriers of the A53T/G209A point mutation in the α-synuclein gene (SNCA) (n = 29), and respective age-/sex-matched controls. Levels of total α-synuclein were assessed using an in-house ELISA assay. RESULTS: A statistically significant increase of α-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of α-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma α-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients. CONCLUSION: Increased α-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of α-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of α-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/date> "2020-04" . <https://discovery.ucl.ac.uk/id/document/1111184> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/volume> "73" . <https://discovery.ucl.ac.uk/id/publication/ext-cc3ccb4cd982e044feae983a328927d9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-cc3ccb4cd982e044feae983a328927d9> <http://xmlns.com/foaf/0.1/name> "Parkinsonism & Related Disorders"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-cc3ccb4cd982e044feae983a328927d9> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-54487ad968e9a9a51b253a73ba1fb05c> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-54487ad968e9a9a51b253a73ba1fb05c> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-335cbd130f5a6d6cc081544213a9e798> . <https://discovery.ucl.ac.uk/id/eprint/10099182> 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<http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-a567cda28384c079694080d451a07fc9> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5ab5abc8ee219fd5cb0977a4fe6b7087> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-5ab5abc8ee219fd5cb0977a4fe6b7087> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c37145af1072d789a04ba1b4522bf6d9> . <https://discovery.ucl.ac.uk/id/eprint/10099182> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> . <https://discovery.ucl.ac.uk/id/eprint/10099182#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-c37145af1072d789a04ba1b4522bf6d9> . <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> <http://xmlns.com/foaf/0.1/familyName> "Bozi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bdfdd4e9c05aecb0c8bb5de7373c4a61> <http://xmlns.com/foaf/0.1/name> "M Bozi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> <http://xmlns.com/foaf/0.1/givenName> "PC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> <http://xmlns.com/foaf/0.1/familyName> "Ioannou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-34105de621bbc833f2339979530fffbc> <http://xmlns.com/foaf/0.1/name> "PC Ioannou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> <http://xmlns.com/foaf/0.1/familyName> "Vekrellis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3f99d40319d9a96e7cb0241c5d1f899f> <http://xmlns.com/foaf/0.1/name> "K Vekrellis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> <http://xmlns.com/foaf/0.1/familyName> "Athanasiadou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9a60dfb305f08b5f2c4c0fad84856a3c> <http://xmlns.com/foaf/0.1/name> "A Athanasiadou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> <http://xmlns.com/foaf/0.1/familyName> "Antonellou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2cb5b817d834866a38339dee3bba0eaf> <http://xmlns.com/foaf/0.1/name> "R Antonellou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed39245acca9c4f3b4e1965d4f24194b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ed39245acca9c4f3b4e1965d4f24194b> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed39245acca9c4f3b4e1965d4f24194b> <http://xmlns.com/foaf/0.1/familyName> "Kouloulia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ed39245acca9c4f3b4e1965d4f24194b> <http://xmlns.com/foaf/0.1/name> "S Kouloulia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> <http://xmlns.com/foaf/0.1/familyName> "Maniati"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-30d67e6b47c406bfff8f04fb84797797> <http://xmlns.com/foaf/0.1/name> "M Maniati"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> <http://xmlns.com/foaf/0.1/familyName> "Koros"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5adb1f67130a29368d8f2f2cd854f581> <http://xmlns.com/foaf/0.1/name> "C Koros"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a567cda28384c079694080d451a07fc9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a567cda28384c079694080d451a07fc9> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a567cda28384c079694080d451a07fc9> <http://xmlns.com/foaf/0.1/familyName> "Galaziou"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a567cda28384c079694080d451a07fc9> <http://xmlns.com/foaf/0.1/name> "A Galaziou"^^<http://www.w3.org/2001/XMLSchema#string> . 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