@article{discovery10099182,
           month = {April},
           pages = {35--40},
            year = {2020},
           title = {Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease},
          volume = {73},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
         journal = {Parkinsonism \& Related Disorders},
             url = {https://doi.org/10.1016/j.parkreldis.2020.03.014},
          author = {Emmanouilidou, E and Papagiannakis, N and Kouloulia, S and Galaziou, A and Antonellou, R and Papadimitriou, D and Athanasiadou, A and Bozi, M and Koros, C and Maniati, M and Vekrellis, K and Ioannou, PC and Stefanis, L},
        abstract = {BACKGROUND: Variations of {\ensuremath{\alpha}}-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients. METHODS: Serum and plasma were obtained from PD patients without known mutations (GU-PD, n�=�124)), carriers of the A53T/G209A point mutation in the {\ensuremath{\alpha}}-synuclein gene (SNCA) (n�=�29), and respective age-/sex-matched controls. Levels of total {\ensuremath{\alpha}}-synuclein were assessed using an in-house ELISA assay. RESULTS: A statistically significant increase of {\ensuremath{\alpha}}-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of {\ensuremath{\alpha}}-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma {\ensuremath{\alpha}}-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients. CONCLUSION: Increased {\ensuremath{\alpha}}-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of {\ensuremath{\alpha}}-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of {\ensuremath{\alpha}}-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele.},
        keywords = {A53T, Alpha-synuclein, Parkinson disease, Plasma, Serum}
}