eprintid: 10099114
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/09/91/14
datestamp: 2020-06-02 15:50:56
lastmod: 2021-09-20 00:10:20
status_changed: 2020-06-02 15:50:56
type: article
metadata_visibility: show
creators_name: Darolti, I
creators_name: Wright, AE
creators_name: Mank, JE
title: Guppy Y chromosome integrity maintained by incomplete recombination suppression
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
keywords: gametologs, non-recombining region, poecilid, sex-linked genes
note: Copyright © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: The loss of recombination triggers divergence between the sex chromosomes and promotes degeneration of the sex-limited chromosome. Several livebearers within the genus Poecilia share a male-heterogametic sex chromosome system that is roughly 20 million years old, with extreme variation in the degree of Y chromosome divergence. In P. picta, the Y is highly degenerate and associated with complete X chromosome dosage compensation. In contrast, although recombination is restricted across almost the entire length of the sex chromosomes in P. reticulata and P wingei, divergence between the X and the Y chromosome is very low. This clade therefore offers a unique opportunity to study the forces that accelerate or hinder sex chromosome divergence. We used RNA-seq data from multiple families of both P. reticulata and P. wingei, the species with low levels of sex chromosome divergence, to differentiate X and Y coding sequence based on sex-limited SNP inheritance. Phylogenetic tree analyses reveal that occasional recombination has persisted between the sex chromosomes for much of their length, as X- and Y-linked sequences cluster by species instead of by gametolog. This incomplete recombination suppression maintains the extensive homomorphy observed in these systems. In addition, we see differences between the previously identified strata in the phylogenetic clustering of X-Y orthologs, with those that cluster by chromosome located in the older stratum, the region previously associated with the sex-determining locus. However, recombination arrest appears to have expanded throughout the sex chromosomes more gradually instead of through a stepwise process associated with inversions.
date: 2020-05-19
date_type: published
official_url: https://doi.org/10.1093/gbe/evaa099
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1786854
doi: 10.1093/gbe/evaa099
pii: 5840475
lyricists_name: Mank, Judith
lyricists_id: JEMAN95
actors_name: Mank, Judith
actors_id: JEMAN95
actors_role: owner
full_text_status: public
publication: Genome Biology and Evolution
event_location: England
citation:        Darolti, I;    Wright, AE;    Mank, JE;      (2020)    Guppy Y chromosome integrity maintained by incomplete recombination suppression.                   Genome Biology and Evolution        10.1093/gbe/evaa099 <https://doi.org/10.1093/gbe%2Fevaa099>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10099114/1/evaa099-1.pdf