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<https://discovery.ucl.ac.uk/id/eprint/10098872> <http://purl.org/dc/terms/title> "Purification and functional characterization of brain and recombinant chimaerin, a p21rac GTPase activating protein"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10098872> <http://purl.org/ontology/bibo/abstract> "n-chimaerin is a GAP for the ras-related p21rac. A 45 kDa brain protein\r\n(p45) immune reactive to anti-n-chimaerin polyclonal antibodies had selective\r\np21 rac GAP activity, using an overlay assay. p45-chimaerin was purified 400-\r\nfold from rat brain by column chromatography. Tryptic peptides contained\r\nsequences identical to that predicted from α2-chimaerin cDNA, a splice variant\r\nencoding a divergent N-terminal with a SH2 domain. Thus, p45-chimaerin\r\nprobably corresponds to SH2-containing (α2) chimaerin. A 35 kDa p21rac GAP\r\n(p35) detected in detergent soluble membrane fractions, immunoreactive to\r\nchimaerin antiserum was likely to represent n-chimaerin (α1-chimaerin). Diverse\r\nGAPs for the rho/rac family were present in the brain; p45-chimaerin was widely\r\ndistributed in brain regions except cerebellum, and was present in both\r\nmembrane and cytosolic fractions.\r\nBoth native and recombinant a2-chimaerin exhibited p21rac GAP activity\r\nin solution, which was stimulated by phosphatidylserine with a synergistic effect\r\nby phorbol esters. GAP activity of α2-chimaerin was unaffected by its SH2\r\ndomain. In contrast to α1-chimaerin, α2-chimaerin bound more phorbol ester\r\nin the presence of phosphatidylinositol than of phosphatidylserine. α2-Chimaerin\r\nwas phosphorylated by PKC and PKA in vitro. Brain proteins interacting with\r\nα2-chimaerin were detected using 32P-labelled PKC phosphorylated chimaerin.\r\nA 60 kDa protein interacting with the SH2 domain of α2-chimaerin was purified;\r\npeptide sequences showed it to be novel. Two peptides had similarity to the\r\nconsensus sequences of a MAP kinase substrate and a SH2 binding domain.\r\nThese data suggest that α2-chimaerin plays a physiological role in neuronal\r\nsignal transduction involving SH2-linked receptor/tyrosine kinase and p21rac\r\nsignalling pathways."^^<http://www.w3.org/2001/XMLSchema#string> .
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