eprintid: 10098554
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/09/85/54
datestamp: 2020-05-27 13:56:06
lastmod: 2021-09-22 22:28:52
status_changed: 2020-05-27 13:56:06
type: article
metadata_visibility: show
creators_name: Feng, Y
creators_name: Powell, L
creators_name: Vassallo, AJ
creators_name: Hamer, M
creators_name: Stamatakis, E
title: Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D16
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: The potential of physical activity (PA) to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in 10 British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998 and 2003). Alcohol‐related cancer mortality included oral cavity, throat, larynx, oesophagus, liver, colorectal, stomach and female breast (conservative definition), and additionally pancreas and lung (broad definition). Alcohol consumption was categorised into six groups based on the UK units/week: (a) never‐drinkers, (b) ex‐drinkers, (c) occasional drinkers, (d) within guidelines (<14 UK units/week [women]; <21 UK units/week [men]), (e) hazardous (14‐35 [women]; 21‐49 [men]) and (f) harmful (>35 [women]; >49 [men]). PA was categorised using two dichotomous classifications based on the lower (7.5 Metabolic Equivalent Task [MET]‐hours/week) and upper (15 MET‐hours/week) recommended limits. Using Cox proportional hazard models, we found a strong direct association between alcohol consumption and mortality risk of alcohol‐related cancers, with a significantly higher risk among ex‐drinkers (Hazard ratio [HR] = 1.46, 95% confidence interval [CI] = [1.09, 1.94]), drinkers who consumed hazardous (HR = 1.39, 95% CI = [1.06, 1.83]) and harmful amounts of alcohol (HR = 1.62, 95% CI = [1.13, 2.30]) compared to never‐drinkers in the fully adjusted model. The increased mortality risks were substantially attenuated when participants in these drinking groups exercised >7.5 MET‐hours/week. PA could be promoted as an adjunct risk minimisation measure for alcohol‐related cancer prevention.
date: 2020-11-15
date_type: published
official_url: https://doi.org/10.1002/ijc.33052
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1783587
doi: 10.1002/ijc.33052
lyricists_name: Hamer, Mark
lyricists_id: MHAME21
actors_name: Hamer, Mark
actors_id: MHAME21
actors_role: owner
full_text_status: public
publication: International Journal of Cancer
volume: 147
number: 10
pagerange: 2754-2763
event_location: United States
issn: 1097-0215
citation:        Feng, Y;    Powell, L;    Vassallo, AJ;    Hamer, M;    Stamatakis, E;      (2020)    Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults.                   International Journal of Cancer , 147  (10)   pp. 2754-2763.    10.1002/ijc.33052 <https://doi.org/10.1002/ijc.33052>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10098554/1/Alcohol_PA_CancerMortality_IJC.pdf