<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10098423> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/title> "Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/abstract> "Through a genetic screen in zebrafish, we identified a mutant with disruption to myelin in both the CNS and PNS caused by a mutation in a previously uncharacterized gene, slc12a2b, predicted to encode a Na+, K+, and Cl− (NKCC) cotransporter, NKCC1b. slc12a2b/NKCC1b mutants exhibited a severe and progressive pathology in the PNS, characterized by dysmyelination and swelling of the periaxonal space at the axon–myelin interface. Cell-type–specific loss of slc12a2b/NKCC1b in either neurons or myelinating Schwann cells recapitulated these pathologies. Given that NKCC1 is critical for ion homeostasis, we asked whether the disruption to myelinated axons in slc12a2b/NKCC1b mutants is affected by neuronal activity. Strikingly, we found that blocking neuronal activity completely prevented and could even rescue the pathology in slc12a2b/NKCC1b mutants. Together, our data indicate that NKCC1b is required to maintain neuronal activity–related solute homeostasis at the axon–myelin interface, and the integrity of myelinated axons."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/date> "2020-07-06" .
<https://discovery.ucl.ac.uk/id/document/1107116> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/volume> "219" .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/issue> "7" .
<https://discovery.ucl.ac.uk/id/publication/ext-77f0620c6a2ce05d3ca08d1c0762da5f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-77f0620c6a2ce05d3ca08d1c0762da5f> <http://xmlns.com/foaf/0.1/name> "Journal of Cell Biology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-77f0620c6a2ce05d3ca08d1c0762da5f> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4589a10b7bc368aa60d6e2bc26e13f1c> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4589a10b7bc368aa60d6e2bc26e13f1c> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-115356ae7423505978118dc2f5fd94d7> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-115356ae7423505978118dc2f5fd94d7> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7c2186da55943b36eebc1359b57881b> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e7c2186da55943b36eebc1359b57881b> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-837976e2f4df42833768aab89d50dcac> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-837976e2f4df42833768aab89d50dcac> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> .
<https://discovery.ucl.ac.uk/id/eprint/10098423> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10098423#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10098423#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> .
<https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> <http://xmlns.com/foaf/0.1/familyName> "Rubio-Brotons"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c025d00854bbbd53066bf1600d5d894> <http://xmlns.com/foaf/0.1/name> "M Rubio-Brotons"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> <http://xmlns.com/foaf/0.1/givenName> "DA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> <http://xmlns.com/foaf/0.1/familyName> "Lyons"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-edfc7229b05cd2a0b12f2e921a05cc1c> <http://xmlns.com/foaf/0.1/name> "DA Lyons"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> <http://xmlns.com/foaf/0.1/givenName> "SK"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> <http://xmlns.com/foaf/0.1/familyName> "Benito-Kwiecinski"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e55dd7164c11384e48311a77cd1b33eb> <http://xmlns.com/foaf/0.1/name> "SK Benito-Kwiecinski"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> <http://xmlns.com/foaf/0.1/familyName> "Kegel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7555556a99ee2f69ca8f3afac3c6616> <http://xmlns.com/foaf/0.1/name> "L Kegel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> <http://xmlns.com/foaf/0.1/givenName> "W"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> <http://xmlns.com/foaf/0.1/familyName> "Möbius"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-116c0245ba4bf14468fe6925764d308a> <http://xmlns.com/foaf/0.1/name> "W Möbius"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> <http://xmlns.com/foaf/0.1/givenName> "JM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> <http://xmlns.com/foaf/0.1/familyName> "Bin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-80af9ca2646e8be33f5139e4d97bc918> <http://xmlns.com/foaf/0.1/name> "JM Bin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> <http://xmlns.com/foaf/0.1/givenName> "KLH"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> <http://xmlns.com/foaf/0.1/familyName> "Marshall-Phelps"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-936765ee91c20e9671dae0c30f11cf84> <http://xmlns.com/foaf/0.1/name> "KLH Marshall-Phelps"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> <http://xmlns.com/foaf/0.1/givenName> "RJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> <http://xmlns.com/foaf/0.1/familyName> "Poole"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ff46e38ab74de235cd84a6a344b4d198> <http://xmlns.com/foaf/0.1/name> "RJ Poole"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> <http://xmlns.com/foaf/0.1/familyName> "Suminaite"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e4177a04f9fdb6c6932dca7c85c20760> <http://xmlns.com/foaf/0.1/name> "D Suminaite"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> <http://xmlns.com/foaf/0.1/givenName> "MR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> <http://xmlns.com/foaf/0.1/familyName> "Livesey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-77022382671304dcf3a56ad6b8280565> <http://xmlns.com/foaf/0.1/name> "MR Livesey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> <http://xmlns.com/foaf/0.1/familyName> "Ruhwedel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e907ab4830b1d280aa27557da1c8aef1> <http://xmlns.com/foaf/0.1/name> "T Ruhwedel"^^<http://www.w3.org/2001/XMLSchema#string> .
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