eprintid: 10098340
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/09/83/40
datestamp: 2020-05-27 12:05:42
lastmod: 2021-09-20 00:10:19
status_changed: 2020-10-14 18:12:06
type: article
metadata_visibility: show
creators_name: Furman, BLS
creators_name: Metzger, DCH
creators_name: Darolti, I
creators_name: Wright, AE
creators_name: Sandkam, BA
creators_name: Almeida, P
creators_name: Shu, JJ
creators_name: Mank, JE
title: Sex chromosome evolution: So many exceptions to the rules
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
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abstract: Genomic analysis of many non-model species has uncovered an incredible diversity of sex chromosome systems, making it possible to empirically test the rich body of evolutionary theory that describes each stage of sex chromosome evolution. Classic theory predicts that sex chromosomes originate from a pair of homologous autosomes and recombination between them is suppressed via inversions to resolve sexual conflict. The resulting degradation of the Y chromosome gene content creates the need for dosage compensation in the heterogametic sex. Sex chromosome theory also implies a linear process, starting from sex chromosome origin and progressing to heteromorphism. Despite many convergent genomic patterns exhibited by independently evolved sex chromosome systems, and many case studies supporting these theoretical predictions, emerging data provide numerous interesting exceptions to these long-standing theories, and suggest that the remarkable diversity of sex chromosomes is matched by a similar diversity in their evolution. For example, it is clear that sex chromosome pairs are not always derived from homologous autosomes. Also, both the cause and mechanism of recombination suppression between sex chromosome pairs remain unclear, and it may be that the spread of recombination suppression is a more gradual process than previously thought. It is also clear that dosage compensation can be achieved in many ways, and displays a range of efficacy in different systems. Finally, the remarkable turnover of sex chromosomes in many systems, as well as variation in the rate of sex chromosome divergence, suggest that assumptions about the inevitable linearity of sex chromosome evolution are not always empirically supported, and the drivers of the birth-death cycle of sex chromosome evolution remain to be elucidated. Here, we concentrate on how the diversity in sex chromosomes across taxa highlights an equal diversity in each stage of sex chromosome evolution.
date: 2020-06
date_type: published
official_url: https://doi.org/10.1093/gbe/evaa081
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1779790
doi: 10.1093/gbe/evaa081
pii: 5823304
lyricists_name: Coelho De Almeida, Pedro
lyricists_name: Mank, Judith
lyricists_id: PCOEL82
lyricists_id: JEMAN95
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Genome Biology and Evolution
volume: 12
number: 6
pagerange: 750-763
event_location: England
citation:        Furman, BLS;    Metzger, DCH;    Darolti, I;    Wright, AE;    Sandkam, BA;    Almeida, P;    Shu, JJ;           Furman, BLS;  Metzger, DCH;  Darolti, I;  Wright, AE;  Sandkam, BA;  Almeida, P;  Shu, JJ;  Mank, JE;   - view fewer <#>    (2020)    Sex chromosome evolution: So many exceptions to the rules.                   Genome Biology and Evolution , 12  (6)   pp. 750-763.    10.1093/gbe/evaa081 <https://doi.org/10.1093/gbe%2Fevaa081>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10098340/1/Coelho_evaa081.pdf